Le Lavandou
France
Long-term weather forecast
Long-term weather forecast
November weather forecast and climate
Le Lavandou, France
Sea temperature
In Le Lavandou, France, in Noviembre, the average water temperature is 17.3°C (63.1°F).
Note: Swimming in 17.3°C (63.1°F) is not enjoyable for the majority. Controlling breathing becomes progressively more difficult as surface water temperature decreases below 21°C (69.8°F).
Daylight
In Noviembre, the average length of the day is 9.7h.
What is the sea temperature in Noviembre in Le Lavandou?
In Le Lavandou, France, the average seawater temperature in Noviembre is 17.3°C (63.1°F). For swimming, a surface water temperature of 17.3°C (63.1°F) is not enjoyable for the majority. It is not considered safe, as controlling breathing becomes progressively more difficult as water temperature decreases below 21°C (69.8°F).
What is the average length of the day in Noviembre in Le Lavandou?
The average length of the day in Noviembre is 9.7h.
Average sea temperature in November - Le Lavandou, France
 - Average sea temperature in November: 17.3°C
The best month for swimming (with the highest average sea temperature) is August (23°C).
The coldest month (with the lowest average sea temperature) is February (13.1°C).
Average daylight in November - Le Lavandou, France
 - Average daylight in November: 9.7h
The month with the longest days is June (Average daylight: 15.3h).
The month with shortest days is December (Average daylight: 9.1h).


text:
Often considered expendable, wastewater from commercial buildings and sewage treatment plants (STP) has value as a heat source, offering a sustainable and in some cases economical avenue to a lower energy footprint of facilities. Today, heat recovery from wastewater has been successfully implemented at STPs, in residential or commercial buildings, and in large sewage pipelines. About 25% of a building's energy is used to heat water, which ends up in shower drains and dishwasher or laundry water, typically discharged to sewers at about 18 °C to 20 °C (64 ºF to 77 ºF).
North America and Europe together produce about 300 million m3/day of wastewater flowing through sewers, with a potential to replace 1.5 billion MWh of natural gas used for space heating and heating domestic water. The U.S. DOE estimates that annually, 350 billion kW of hot water goes down the drain, roughly $35 billion worth of energy (at $0.10 per kW). A challenge, however, has been to introduce heat recovery solutions that are sized for the existing infrastructure and provide a reasonable ROI for wider adoption. One company that appears to be succeeding in both areas is Sharc Energy Systems, which has developed a system that combines solids removal and a standard heat pump. It claims that operating at domestic wastewater temperatures makes the heat pumps 25% to 30% more efficient than ground source heat pumps.
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source: m-a-p/FineFineWeb


Tracy McKenzie, Distinguished Teaching Award
When the UW history department hired Tracy McKenzie in 1988, he filled a position vacated by legendary Professor Tom Pressly, a Distinguished Teaching Award winner. At the time, a faculty member predicted McKenzie would "honor the position held by Professor Pressly."
Not only has McKenzie honored it, he has followed in Pressly's footsteps by winning a 1998 Distinguished Teacher Award himself.
"For the last few years, undergraduate students have been telling me what a good teacher Tracy McKenzie was, and my visit to his classroom confirmed their impression," one colleague says. "What I witnessed was a polished, lucid, and engaging explanation of how the Union began disintegrating between 1848 and 1858. His teaching surely helps to bring distinction to the history department."
The same students who describe him as a "fabulous professor" and "charismatic" also note receiving strong criticism and low grades from McKenzie, who teaches Civil War history. (His comments on student papers can rival the papers themselves in length.) "His standards may be high, (but) no one ever complained that they were unfair or that they did not get the guidance they needed to meet those standards," a student comments.
"I've always thought that the role teachers should play is to follow the old newspaper motto to 'comfort the afflicted and afflict the comfortable,' " McKenzie says. "I don't intend on leaving my students in a self-congratulatory mood. I want them examining and questioning their attitudes--not necessarily discarding them, but examining them."
"Tracy takes risks as a teacher," a colleague wrote. "He is scrupulously careful to distinguish between history and his own opinions, but at the same time he models in himself the claim that he urges upon his students: that history demands of all of us that we engage ourselves personally with it."
"The idea is not that at age 21 [students] have all the answers," McKenzie says, "but that they can articulate the conflicts around their world view."--Nedra Floyd Pautler, UW News and Information
Return to the Beginning of "The Best of 1998"
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Table of Contents


text:
1. In the blue left-hand menu bar, select classroom actions.
2. Click 'Add Entry'
3. Tap the + icon and tap "Activity"
4. Tap on the child(ren) that this activity will apply to.
5. Write a description of the activity.
6. Click 'Create Entry'
This will add the activity to the daily reports of all the children that were selected.

source: openbmb/Ultra-FineWeb


One of the behavioral Visual Acuity analysis testperformed are the optokinetic response (OKR) test and OMR. From the analysis of this test, visual acuity and contrast sensitivity could be deduced. For the test, zebrafish larvae are immobilized in petri dishes above an infrared light. The light emitted rotating grating patterns around the larvae, and the patterns elicited eye movement, which was recorded in real time by an infrared-sensitive Camera.


Contents - Index
Master Pitch Range, Pitch Tab
User Level: Basic, Advanced
MIDI File Usage: Playback, Notate
Normally, you should try to restrict the pitch range to the smallest possible range that contains all notes present in the audio file, but not beyond. This will improve both conversion speed and accuracy. You can use the Auto Detect feature to help set this range. You can in theory specify a pitch range from C0 up to G10 (MIDI note numbers 0 through 127, if the sample rate of the audio file is 44100 Hz), assuming Middle C is C5 (MIDI note number 60), but we don't recommend it. A larger range also requires more memory. For comparison, a piano has a pitch range of A1 to C9. The default range changes based on the range of the Audio Instrument you select. Generally, a 4 octave range is sufficient. Be especially careful not to set the Low note too high; if the created MIDI file contains many wrong notes, try lowering the Low note by an octave. (If you have the Ensemble Edition of intelliScore and you are using an ensemble that contains multiple pitch ranges, the pitch range on the Pitch tab sets the overall range; pitches outside the overall range are ignored even if one or more of the ensembles pitch ranges include them. The pitch range on the Pitch tab is duplicated as the Master Pitch Range in the Ensemble Editor; changes to one affect the other.) You can specify the pitch range by using the slider, or by typing the note value in the High and Low boxes. To set the low note using the slider, drag the slider knob down to the desired value. The value you select is displayed in the Low box. To set the high note, drag the slider knob up to the desired value while pressing the key. The value you select is displayed in the High box.
The first example has a pitch range of E5 - G5. The second example has a pitch range of E5 - E6.


How to Connect to iTunes
Apple's iTunes media management software allows you to sync media with multiple devices under a single user ID. You must take time to authorize computers, manually sync your devices and enable Home Sharing to take advantage of all the ways you can connect to iTunes.
Part One of Four:
Choosing Computers to Connect to iTunes
Edit
 1. 1
 Decide which computer you want to use to manage your iTunes library. It should be a computer that has plenty of storage, has access to a strong Wi-Fi network and is available frequently for your use.
 2. 2
 Create up t o 5 user accounts on this computer. The content that you download onto iTunes can be authorized to play on up to 5 different computers that have iTunes. This includes the following 2 situations:
 - You can own 5 different computers, download iTunes and authorize your Apple ID to access your music library.
 - You can set up 5 different user accounts on the computer. Although you will only download iTunes a single time, each user profile will count as a single authorized use of iTunes with the account, as if you had downloaded iTunes 5 different times to use with the account.
 3. 3
 Manage the computers/authorized accounts regularly. You can authorize new computers and de-authorize other computers, depending upon your connection needs.
 - Download iTunes on a new computer. Go to the iTunes Store. In the Store menu or Advanced menu choose the option to "Authorize this Computer." Enter your Apple ID to connect it to your iTunes library.
 - De-authorize a computer if you have reached the 5 accounts but want to replace one computer with another. Open iTunes on the computer that has been authorized. You will need Internet access to do so. Go to the iTunes Store. Click on the Store menu or Advanced menu. Choose "De-authorize this Computer" and enter your Apple ID. You will no longer have access to your library on this computer.
 - If you no longer have access to computers that have been authorized in the past, you can deauthorize all computers and re-authorize them one by one. Go into iTunes on your main computer. Access the iTunes store. Sign in using the Account button and enter your Apple ID. Find the option to deauthorize all computers and click it.[1]
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Part Two of Four:
Connecting Devices to iTunes
Edit
 1. 1
 Remove automatic syncing from your apps on your device. Go to the Settings app. Find "Restrictions" in the general settings.
 - Slide the "In-App Purchases" to off.
 - This will restrict the allowed content to just those apps you have manually downloaded to the device.
 - Repeat this step on all of your devices that you plan to sync into the iTunes library.[2]
 2. 2
 Find a USB charger cable for each of your devices. In some cases, you may have been provided a Firewire or Lightening cable to connect your device to a computer. You can connect an unlimited number of devices to a single Apple ID, but you will need to control what portions of your library you want to use on each device.
 3. 3
 Start the iTunes Connect your first Apple device to your computer. If it asks you whether you want to sync your device to your iTunes library, say "no" at first, unless you want all your media files to immediately download onto this device.
 4. 4
 Choose the manual sync option for most devices, since they have different storage limits and user capabilities. For example, an iPod Shuffle will have lower content limits than an iPad or iPhone.
 5. 5
 Click on the tabs, such as "music," "movies" and "podcasts. If you do not see these options, click on the device name in the left hand column of your iTunes screen to gain access to the library and your device.
 6. 6
 Go to each section and manually sync the information you want to share on this particular device. Wait for the device to sync. Once all the information you want is on the device, eject it using the symbol next to the device name.
 7. 7
 Repeat the manual syncing process with each Apple device you own. Although you can connect each device to a single iTunes account, you can control the information according to your preferences.
 - You can't connect a device to more than one Apple ID.
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Part Three of Four:
Managing Music on Different Devices
Edit
 1. 1
 Add media files onto your main iTunes library before making changes in how you manage your music. Download new songs, videos or podcasts from the iTunes store or rip CDs into your iTunes account.
 2. 2
 Opt to create a different iTunes library for each device, if you don't want to manually sync your device each time you connect it to iTunes.
 - If you have a Mac computer, you should hold down the Option key while you open iTunes.
 - If you have a Windows computer, you should hold down the Shift key while you open iTunes.
 - Choose "Create Library" in the dialog box, and then name it a different name. You can do this for each device you plan to connect to iTunes.
 - Open iTunes with the new library file. Go to the iTunes menu and choose Preferences and the Advanced tab.
 - Deselect the line that says, "Copy files to iTunes Media folder when adding to library" and you will avoid making extra copies of files that you already have on your computer.
 - Add the specific files you want in this library by adding individually through the File menu or clicking and dragging from one iTunes library into another.
 3. 3
 Repeat with each remaining device-specific iTunes library you want to create. This method is best if you have a very different mix of videos, music and podcasts that you want to connect to your different Apple devices.
 4. 4
 Choose to create different iTunes playlists, in place of adding new iTunes libraries, if you want to put different music on each device. Add playlists to your main iTunes account and name them according to your device.
 - Go through your iTunes music library and add songs and albums to the playlist of your choice.
 5. 5
 Plug in your device using your USB cable. Go to the Music tab and choose to sync a specific playlist to your device each time you connect it to iTunes. You can add music to that playlist when the device is unplugged and it will automatically be synced the next time you connect it.[3]
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Part Four of Four:
Using Apple Home Sharing
Edit
 1. 1
 Connect your computer to a Wi-Fi network that you use regularly at home.
 2. 2
 Connect your Apple devices, such as iPhones and iPads, to the same wireless network. Connect your Apple TV, if you own one, because it has the best capabilities for sharing iTunes content.
 3. 3
 Turn on Home Sharing on each computer that is connected to your Apple ID. You will need to open iTunes and click on Home Sharing in the Sharing tab on the left hand side. Turn on Home Sharing on the computer.
 - You will see the other computers or user's libraries listed in the Sharing section as soon as they also enable Home Sharing.[4]
 4. 4
 Turn the Home Sharing function on individually with each device. Go to the Settings icon. Find the Sharing tab and enable Home Sharing. You can now connect and play your iTunes libraries on different devices within your Wi-Fi network.[5]
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Community Q&A
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 - How do I connect my iPhone 5 to iTunes?
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 - Follow the instructions listed in the article above.
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 - How do I connect an iPad to iTunes?
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 - Go to the Music app. Then sign in. It is essentially the same as how you connect with your iPhone, if you have one.
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 - From the home screen, go to the App Store, choose Featured, and scroll to the bottom of the screen. Alternately, go to Settings, scroll down until you find iCloud, and tap it.
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Tony Blair Institute for Global Change
Tony Blair Institute for Global Change
Tech & Digitalisation
From Outer Space to the Human Cell: The Moonshots That Could Save Humanity
Paper25th January 2023
Each year our Moonshots series highlights new frontiers where breakthroughs in science and technology are being used to solve some of the biggest problems of our time.
Since our first publication in 2021, huge strides have been made in health, energy, resilient food systems and more, helping us to live healthily for longer, while responding to the most urgent climate challenges around the globe.
As we look ahead to 2023 these themes remain. This year's contributors describe the need for a multi-pronged approach to tackle challenges on many fronts: from looking to space to help meet our energy needs, to using biology to optimise health, to renewed efforts to put the power of computing and artificial intelligence (AI) to work.
Pippa Malmgren opens this year's edition with a literal moonshot – detailing efforts led by the US and by China to establish permanent bases on the Moon from which to further explore space with a view to solving problems here on Earth. She argues that such exploration could be an engine for inclusion and clean energy, but warns that space could become just another battlefield for Earth-bound geopolitics.
Health care and biotech remain core topics, with personalised biotyping emerging as a way to pre-emptively treat mental-health conditions, as outlined by Leanne Williams and Ruth O'Hara. Gordon Sanghera describes Oxford Nanopore's DNA-sequencing and genomic technology, which offers the possibility that we will be able to access real-time alerts so we can head off threats to our food system, and even the next pandemic, before they take hold. Trevor Martin of Mammoth Biosciences discusses the role of CRISPR and gene therapies in enabling us to not only detect but also prevent disease.
This year's list includes quantum computing for the first time, and its potential benefits in areas as diverse as rapid drug discovery and improving cybersecurity. Tim Menke sets out Atlantic Quantum's efforts to create more accurate quantum-computing capability and to scale processor sizes without compromising performance – critical to delivering on the promise of quantum.
In the realm of transport and energy, several contributors are optimistic that work to scale clean technologies will soon prove fruitful. Nick Hawker describes technical breakthroughs in Fusion while Val Miftakhov details ZeroAvia's efforts to create zero-emission aviation through the use of hydrogen-electric fuel cells. Meanwhile Ashwin Shashindranath and Eliza Eddison set out what it will take to deliver these innovations to market – including financing deep-tech climate ventures and the role of policy and incentives in accelerating the shift to renewable technologies.
Finally, we include a moonshot generated by ChatGPT. Generative (AI) has hit the mainstream this year, with ChatGPT, DALL-E 2 and Stable Diffusion creating text and images with widespread applications. ChatGPT's contribution sets out how it could speed up the design, testing and optimisation of novel materials and new transport technologies – assuming AI systems continue to master the intricacies of human creativity.
If you're working on these themes, or are interested in the applications of these moonshots, please do contact us directly (_EMAIL_ or _EMAIL_).
"Humankind is returning to the Moon to solve Earth's problems"
PIPPA MALMGREN, AUTHOR, FORMER US PRESIDENTIAL ADVISOR AND TECH ENTREPRENEUR
We are at a once-in-a-species moment. Humankind is returning to the Moon not just to step on it, but to stay on it, to build on it and to launch from it into the further reaches of space. The Artemis mission – led by NASA and with contributions from the European Space Agency, the Canadian Space Agency and the Japan Aerospace Exploration Agency – as well as China's manned space missions are preparing for spacefaring humans who will soon be living and working in space for one reason – to help solve many Earth-bound problems.
Airbus has recently proved that you can generate unlimited electricity on Earth from space-based solar power. NASA has shown that asteroid mining may soon eliminate the need to rip up our planet for raw materials. President Volodymyr Zelensky has shown us the power of satellite-based WiFi, which can connect everyone everywhere – not only on Earth but also on the Moon and beyond. Google has already announced Aalyria, which will provide interplanetary internet.
Space is not just for the superpowers. Rwanda's space agency aims to ensure satellite-based digital inclusion across Africa. Luxembourg is already a centre for asteroid mining firms. Saudi Arabia is investing in space because space-based solar power may diminish, or even eliminate, the need for hydrocarbons. Private firms are jockeying to offer space-based manufacturing and logistics. In Britain, companies like Pulsar Fusion look set to send humans to Mars and launch rockets beyond our solar system, while Orbex and Skyrora are using the largest 3D printers on the planet to build rockets. Cornwall now has a spaceport that will deliver private satellites into space.
Space can deliver on these advances in less than a decade, but this also brings dangers. The superpowers are already fighting in and for space, blowing up their own satellites, creating fields of metallic debris known as the Kessler Syndrome (think razor blades in a washing machine) trying to prevent others from gaining access to certain orbits. As humankind moves off-world, geopolitics will follow.
"AI is unlocking a new generation of foundational challenges"
NATHAN BENAICH, GENERAL PARTNER
Air Street Capital
I started investing in AI in 2014 and since then I've seen impossible problems become solvable, seemingly overnight, thanks to enormous leaps in transformer-model capabilities. We've documented many of these breakthroughs in our annual State of AI report since 2018.
I view "moonshots" in the context of companies using genuinely novel approaches to solve foundational challenges with immense economic and societal value. One such company is Profluent, which is using large language models to design novel proteins from scratch. Proteins – the biological actuators of life – are complex molecules whose structure is intrinsically linked to their function. Everything that can go wrong or right in a human body is reliant on proteins. Creating new ones can allow us to design drugs that more effectively treat diseases. By modelling proteins as a biological language, Profluent is able to learn the relationships between sequence, structure and function in order to systematically design new classes of therapeutic proteins. The vast majority of proteins in nature are yet to be discovered and "AI-first" approaches give us the promise of exploring this space efficiently and, ultimately, rewriting the language of biology.
"DNA sequencing will enable us to detect the next pandemic in real time"
GORDON SANGHERA, CEO
Oxford Nanopore Technologies
DNA forms the building blocks of life. From food to animals, humans to bacteria and viruses, everything is created with and connected by an underlying source code, based on the combination of four letters, that guides the way we develop and operate. Those four letters can also be chemically corrupted in response to the environment, making the science of genomics increasingly complicated.
The latest DNA-sequencing technology allows scientists to read that code and interpret it in real time so that it can be used to make decisions. Scientists are applying this technology to identify and track mutations in the genomes of viral pathogens, to understand and manage biodiversity, and to determine whether a person, animal or plant is healthy or diseased, and then to act on their conclusions. Genomic technology is also being used to explore the breadth of the human microbiome – the communities of between 10 and 100 trillion microbial organisms that impact everything from oceans and wildlife to human health. Recent advances are now making it possible to interpret those data using artificial intelligence and to monitor and act on insights in real time.
Just as the internet of things allows us to adjust our heating supply from a smartphone, a future internet of living things will make it possible to continuously monitor the microbial DNA in our water supply, soil microbiomes influencing crop yield and the threats emerging in our own bodies, from cancer to influenza. Sensors attached to a toothbrush, for example, could alert us to the presence of cancer, while similar sensing tools in hospitals and other public spaces could help head off the next pandemic. Information is power – and rapid, ubiquitous access to DNA information will transform the way we live and protect the planet.
"Using CRISPR to prevent disease and engineer sustainable crops"
TREVOR MARTIN, CO-FOUNDER AND CEO
Mammoth Biosciences
We are at the beginning of a biotech revolution that is presenting us with new capabilities to programme biology. If we can do this in the same way we programme a computer, that will be transformative for people around the world.
CRISPR is one of the breakthrough technologies at the forefront of this revolution. These technologies can be programmed to go to the code of life – DNA and RNA – and bind specific sequences of it. This potentially opens up many doors: in therapies, by programming a protein to cure a disease; in diagnostics, as a protein that can be programmed to detect if cancer or Covid-19 is present; or even in agriculture, to engineer the crops of the future.
At Mammoth Biosciences we are building this toolkit with an ambition to create the definitive biology search engine. We have already made significant progress, but the moonshot for us is to be able to programme life. Harnessed in the right way, we will be able to improve the lives of


text:
Virtual-reality simulator helps teach surgery for brain cancer
September 24, 2012
A new virtual-reality simulator — including sophisticated 3D graphics and tactile feedback — provides allows neurosurgery trainees to practice essential skills and techniques for brain cancer surgery.
The prototype system, called "NeuroTouch," uses 3D graphics and haptic (sense of touch) technology to provide a realistic look and feel for practice in performing common tasks in brain cancer surgery. Lead author Sébastien Delorme, PhD, of the National Research Council Canada and colleagues believe the NeuroTouch system could enhance "acquisition and assessment of technical skills" for neurosurgeons in training.
The NeuroTouch software simulates what the neurosurgeon sees through the operating microscope during surgery — including detailed, lifelike renderings of brain tissue, blood vessels, and tumors. The system also includes haptic tool manipulators, providing tactile feedback similar to what the surgeon would feel during surgery. The simulator runs on computers that are similar to those used to run popular games.
The surgical tasks were developed using 3D reconstructions of MRI scan data from actual patients. With further development, the system could also allow neurosurgeons to simulate and practice actual operations, based on the patient's own MRI scan.
During the development process, the researchers received feedback through an advisory network of teaching hospitals. The 3-D visual graphics received high praise, although the tactile feedback system came in for more criticism. Surgeons testing the system also suggested improvements to the ergonomics of using the simulator.
Neurosurgical residency training programs are challenged to make the most of their resources while maximizing training opportunities for residents. About 90 percent of surgical training is received in the operating room, where residents learn procedures by assisting surgeons with hundreds of operations.
Medical simulators — similar to those used to train airline pilots — are increasingly viewed as a cost-effective complement to traditional surgical training. For example, a commercially available simulator has proven effective in helping trainees perform minimally invasive gallbladder surgery more rapidly, with a lower risk of patient injury.
The NeuroTouch system appears to be a promising tool for extending virtual reality technology to teaching common and important neurosurgery techniques. While it is not the first neurosurgical simulator, it provides key advances over previous systems, particularly in terms of providing real-time graphics and tactile feedback.
The next step will be to evaluate the new system in actual neurosurgical training programs. "First generation NeuroTouch prototypes have been set up in 7 teaching hospitals across Canada, to be used for beta testing and validation and evaluated for integration in a neurosurgery training curriculum," according to Dr. Delorme and colleagues, and a new generation of NeuroTouch simulators is currently being deployed worldwide.

source: HuggingFaceFW/fineweb-edu


text:
Reproductive anomalies associated with the tsetse DNA virus infection in the female tsetse hosts, Glossina morsitans centralis Machado and Glossina morsitans morsitans Westwood, inoculated with the virus during the 3rd instar larval stage were studied and the data compared to those obtained from the control females injected with sterile physiological saline. Virus infected flies had significantly longer first and second pregnancy cycles (P<0.0001) and produced pupae that were of significantly less weight in milligrams (P<0.0001) compared to controls. Transmission of the virus to progeny was not absolute and only 21% of G. m. centralis and 48% of G. m. morsitans first progeny flies from infected females developed salivary gland hypertrophy as a result of transmission from mother to progeny. The virus infected females produced significantly fewere pupae compared to the controls during the experimental period (P<0.00001)
To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.


What Is HALT?
Discover the power of HALT! Unveiling the significance of this acronym for managing hunger, anger, loneliness, and tiredness.
February 14, 2024
Understanding the HALT Acronym
The HALT acronym is an essential tool for recognizing and addressing our basic human needs. By understanding and applying the principles of HALT, we can take better care of ourselves and promote overall well-being. Let's explore the meaning and significance of the HALT acronym.
Introduction to HALT
HALT stands for Hunger, Anger, Loneliness, and Tiredness. These four elements represent common triggers that can have a significant impact on our physical and mental health. When these needs are not met, they can negatively affect our well-being and overall quality of life.
By recognizing HALT triggers, we can proactively address these needs and take appropriate actions to ensure we are taking care of ourselves. It's important to note that HALT is not a diagnosis or a substitute for professional help. Instead, it serves as a guiding framework to help us identify areas where we may need additional support or self-care.
The Significance of the HALT Acronym
Understanding the significance of the HALT acronym is crucial for promoting self-awareness and practicing self-care. Let's take a closer look at each element of HALT and its impact on our well-being:
Element and Impact
Hunger: Hunger can lead to irritability, difficulty concentrating, and low energy levels. It's important to address hunger by nourishing our bodies with regular, balanced meals and snacks.
Anger: Unresolved anger can negatively affect our mental health, relationships, and overall quality of life. By recognizing and managing our anger, we can promote emotional well-being and healthier interactions with others.
Loneliness: Loneliness can have a profound impact on our mental and physical health. It can lead to feelings of sadness, isolation, and reduced self-esteem. Building social connections, seeking support, and engaging in activities we enjoy can help combat loneliness.
Tiredness: Lack of sleep and chronic tiredness can impair cognitive function, mood, and overall productivity. Establishing healthy sleep habits and practicing relaxation techniques can improve the quality of our sleep and combat tiredness.
By understanding the significance of the HALT acronym, we can identify when these needs are not met and take appropriate steps to address them. It's important to prioritize self-care and seek professional help when needed to ensure our overall well-being.
Remember, HALT serves as a starting point for self-reflection and taking care of our basic needs. By recognizing HALT triggers and implementing self-care strategies, we can cultivate a healthier and more balanced lifestyle.
Hunger
Hunger is a fundamental physiological sensation that arises when our body needs nourishment. In the context of the HALT acronym, understanding the effects of hunger on the body and mind is crucial for maintaining overall well-being.
Effects of Hunger on the Body and Mind
When we experience hunger, our body undergoes various physiological changes. These effects can impact both our physical and mental health:
 1. Energy Depletion: Hunger is a sign that our body is running low on fuel. Without proper nourishment, our energy levels decrease, leading to fatigue and a lack of stamina.
 2. Impaired Cognitive Function: Insufficient food intake can impair our cognitive abilities, including concentration, memory, and decision-making. It becomes challenging to focus on tasks and perform at our best.
 3. Mood Changes: Hunger can trigger irritability, mood swings, and a general feeling of discomfort. This is because hunger affects the production of certain neurotransmitters in the brain, such as serotonin, which plays a key role in mood regulation.
 4. Weakened Immune System: Chronic hunger weakens the immune system, making individuals more susceptible to infections and illnesses. It becomes harder for the body to fight off pathogens and maintain optimal health.
Tips for Addressing Hunger
Addressing hunger is essential for maintaining overall well-being. Here are some strategies to help manage and alleviate hunger:
Strategies
Eat Regular Meals: Establish a routine of eating balanced meals at regular intervals throughout the day. This helps to provide a steady source of energy and prevent extreme hunger.
Include Protein and Fiber: Incorporate protein-rich foods, such as lean meats, legumes, and dairy products, into your meals. Additionally, focus on consuming fiber-rich foods like fruits, vegetables, and whole grains, as they promote satiety.
Snack Mindfully: Choose nutritious snacks, such as nuts, yogurt, or fresh fruits, to curb hunger between meals. Avoid relying on unhealthy, sugary snacks that provide temporary relief but lead to energy crashes.
Stay Hydrated: Sometimes, thirst can be mistaken for hunger. Stay hydrated by drinking plenty of water throughout the day.
Listen to Your Body: Pay attention to your body's hunger cues. Eat when you feel hungry and stop when you feel satisfied, rather than overeating or restricting food intake.
Seek Nutritional Guidance: If you struggle with managing hunger or have specific dietary needs, consider consulting with a registered dietitian who can provide personalized nutritional guidance.
By understanding the effects of hunger on our body and mind and implementing strategies to address hunger, we can maintain a balanced and nourished state, promoting overall well-being.
Anger
The Impact of Anger on Mental Health
Anger is an intense emotion that can have a profound impact on mental health. When anger is not managed properly, it can lead to various negative consequences. Chronic anger can contribute to the development of mental health disorders, such as anxiety and depression. Additionally, uncontrolled anger can strain relationships, hinder problem-solving abilities, and negatively affect overall well-being.
Prolonged anger can lead to increased stress levels, which can have detrimental effects on both the mind and body. It can elevate blood pressure, weaken the immune system, and increase the risk of cardiovascular problems. Furthermore, unresolved anger can create a cycle of negative thoughts and emotions, perpetuating a state of distress.
Techniques for Managing Anger
Learning effective techniques for managing anger is crucial for maintaining good mental health and overall well-being. Here are some strategies that can help individuals navigate and cope with their anger:
 1. Identify triggers: Recognize the situations, circumstances, or people that tend to trigger feelings of anger. Being aware of these triggers can help individuals anticipate and prepare for potential anger-inducing situations.
 2. Practice deep breathing: Deep breathing exercises can help calm the body and mind during moments of anger. Taking slow, deep breaths in through the nose and out through the mouth can help regulate emotions and promote a sense of relaxation.
 3. Engage in physical activity: Physical exercise is a powerful way to release built-up tension and reduce anger. Engaging in activities such as jogging, yoga, or boxing can help channel negative energy into a more positive outlet.
 4. Practice mindfulness: Mindfulness techniques, such as meditation or guided imagery, can help individuals become more aware of their anger triggers and develop the ability to respond with greater control. Mindfulness encourages individuals to observe their thoughts and emotions without judgment, allowing for a more balanced perspective.
 5. Seek support: It can be helpful to reach out to trusted friends, family members, or mental health professionals for support. Talking about anger and its underlying causes can provide individuals with insights and guidance on managing their emotions effectively.
By employing these techniques, individuals can gain a better understanding of their anger, develop healthier coping mechanisms, and improve their overall mental well-being. Managing anger in a constructive manner is essential for maintaining healthy relationships, reducing stress, and promoting emotional balance.
Loneliness
Loneliness is a prevalent emotional state that can have a significant impact on overall well-being. It is important to understand the effects of loneliness and implement strategies to combat it.
The Effects of Loneliness on Well-being
Loneliness can affect both mental and physical health. When individuals experience loneliness, they may feel a sense of disconnection from others, leading to emotional distress. The effects of loneliness on well-being can include:
 1. Increased stress: Feelings of loneliness can contribute to heightened stress levels, as individuals may lack the support and social connections needed to cope with life's challenges.
 2. Depression and anxiety: Prolonged loneliness can increase the risk of developing depression and anxiety disorders. The lack of social interaction and meaningful connections can lead to feelings of sadness, hopelessness, and worry.
 3. Impaired cognitive function: Research suggests that loneliness can negatively impact cognitive function, including memory and attention. This impairment may be due to the lack of intellectual stimulation and social engagement.
 4. Weakened immune system: Chronic loneliness has been associated with a weakened immune system, making individuals more susceptible to illnesses and infections.
Strategies for Combating Loneliness
Addressing loneliness requires proactive steps to foster social connections and improve overall well-being. Here are some strategies to combat loneliness:
Strategies
1. Cultivate relationships: Seek out opportunities to meet new people and build meaningful connections. Join social clubs, attend community events, or engage in activities that align with your interests.
2. Stay connected: Maintain regular contact with family and friends. Use phone calls, video chats, or social media to stay in touch, especially if distance or circumstances prevent in-person interactions.
3. Volunteer: Engaging in volunteer work allows you to contribute to your community while also providing opportunities to interact with others who share similar interests.
4. Join support groups: Consider joining support groups or organizations that focus on topics of interest or provide a space for individuals experiencing similar challenges. This can provide a sense of belonging and support.
5. Practice self-care: Engage in activities that promote self-care and well-being. This can include exercise, meditation, pursuing hobbies, or seeking professional help if needed.
6. Seek professional assistance: If feelings of loneliness persist or significantly impact daily life, it may be beneficial to


Did you know?
notam - definition and synonyms
What are red words?
 1. From our crowdsourced Open Dictionary
 notice to airmen; an official announcement circulated to the aviation industry warning them of new high structures, such as cranes, that are being built
 If you want to erect a crane in London of any significant height... there is something called a Notam (Notice to Airmen)... it's a known value that the crane is there, they don't just erect them.
 Submitted from United Kingdom on 16/01/2013
BuzzWord Article
Open Dictionary
the activity of exploring abandoned buildings and other manmade structures
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Macmillan learn live love play


text:
Enhance the look of your learning environment with versatile classroom décor and cut-outs.
The Celebrate Learning Confetti printable cut-outs pack contains:
- 12 large circles
- 12 medium circles
- 15 small circles
When printed on card stock, durable classroom cut-outs are ideal for a variety of purposes.
Play games, label desks, and enhance bulletin boards with Carson-Dellosa's assorted cut-outs. With a wide variety of shapes, colors, and styles, classroom cut-outs are perfect to use as game pieces, cubby tags, and more. To create a cohesive theme, be sure to browse coordinating Celebrate Learning classroom décor.
- Reproducible Rights


Behavioral Metrics 101: Getting the People Side of Your Business Right
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Behavioral Metrics 101: Getting the People Side of Your Business Right
Behavioral metrics is just a fancy way to say, "Measuring the people side of business."
If the concept is unfamiliar, it's because behavioral metrics rarely make it to a P&L. Sure, in most well-run organizations we measure the costs of turnover, employee engagement, and leadership development, but let's take it a step further. For example, think about measuring the difference between the personality profiles of high-performing franchisees and those unable to make the grade. Why are some capable of meeting or exceeding expectations, but others aren't?
By knowing the financial and behavioral gaps that exist between best and worst performers, franchisors can improve their selection of the right franchisee--and influence the performance of existing franchisees. Whatever can be measured can be managed.
The 80/20 rule
Since entering the New Millennium, franchisors have become more interested in applying tools that measure personality and behaviors. This is especially true for franchisors that fall prey to Pareto's Principle, otherwise known as the 80/20 rule. Here, franchisors want to know why 80 percent of royalty income is often generated by the top 20 percent of franchisees. As frustrating as this is, it becomes even more so when the mechanics that cause or predict this elude our grasp. Franchisees make the same investment, receive virtually identical training, are given similar locations and build-outs, yet royalty revenue is all over the place. This gap can be summed up in one phrase: the power of personality.
Qualities of an ideal franchisee
Consider this simple exercise. First, list about 20 qualities that would make for an ideal franchisee, or work from this list if it fits:
Able to follow rules
Big picture thinker
Consensus builder
Deals well with ambiguity
Deals well with pressure
Good listener
Good with numbers
Good with people
Great closer
Holds others accountable
Second, look at the list of qualities and determine which ones are skills and which are behaviors. The difference: skills are learned in school and behaviors come from our personalities. More than likely, the majority of the list will include behaviors. Going through these two simple steps makes it easier to see why behavioral metrics are helpful. Most of what franchisors seek in franchisees lies in the essence of their personality.
Mastering the gap
This five-tier performance pyramid represents a cognitive process for determining who you need to be to achieve results in a particular role or on a given project.
 - Tier I represents the personality of the prospective applicant, existing franchisee, or corporate employee.
 - Tier II represents the job behaviors, how a person needs to act at work. In short, Tier II is all about the job or the position. The list from Step 1 above shows behaviors of the Ideal Franchisee. When selecting a prospective franchisee, an applicant for a corporate position, or when dealing with an existing franchisee, it's critical to know how wide the gap is between the individual's personality and the behavioral requirements of the position. The wider the gap, the more difficult the job becomes, and the more energy required for completion.
 - Tier III denotes the actions necessary to do the job. For example, these actions can include calling on prospective customers, distributing samples, doing X number of presentations, selling retail, or closing new business.
 - Tier IV signifies the metrics we use to measure performance. How many presentations did they do? How much did they sell? How many samples did they distribute? When we drive results, we ultimately achieve our Tier V results.
 - Tier V represents the results, or outcome. For many franchisors, the best Tier V results come in the form of the Ideal Franchisee. When a franchisee matches the behavioral requirements of the position, job performance is typically stellar and usually carried out flawlessly. It can really be a thing of beauty. However, it works both ways. The wider the gap is between a franchisee's personality and the behavioral requirements of the job, the more energy necessary to accomplish the job. Those with the wider gaps go home at the end of the day feeling emotionally drained because they've spent the day going against their natural grain.
By creating a cognitive approach to succeeding in the role of a franchisee, people both with and without the preferred personality for the position can accomplish similar results. Just remember : If you can't measure it, you can't manage it.
Bill Wagner is CEO and co-founder of Accord Management Systems in Westlake Village, Calif. The firm works with franchisors and other franchising professionals to get the people side of business right through behavioral assessments. Exceed your own expectations: send an email to with the subject line containing the title of the position you want to measure. We will send you a link for an online assessment. Enjoy the ride--and Master the Gap!
Published: July 24th, 2013
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Franchise Update Magazine: Issue 2, 2013
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text:
CEE Headquarters: Effectively managing a fragmented growth region
CEE has become a major growth region with high relevance across sectors – especially for Western European companies. However, the high complexity of the region makes management difficult. Due to its fragmentation, CEE requires different management approaches than Western Europe.
The objectives of this study are to understand current trends in CEE management, to show successful approaches across sectors, to define different models of management, and to make clear recommendations for structuring the region.
In this study you find answers to the following guiding questions:
- (How) does the economic development of CEE impact the regional approaches for management in the region?
- How/from where should the region be managed/consolidated?
- What is the best organizational structure at country level per industry?
- What relevance do shared service centers play in CEE?


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Heavy rains recently have increased risk of rot
Thanks to Tropical Storm Beryl and storms it left behind, some St. Johns County potato farmers are moving to get their spuds out of the ground fast before they rot.
St. Johns County agricultural agent Steven Lands said the downpour came a few weeks ahead of normal. The rain has made conditions hotter for the potatoes that are still in the dirt.
If potatoes are left in the ground too long in these conditions, "They will just disintegrate and turn to mush," Lands said.
Lands said that the timing of the rainfall is the major issue. There wasn't enough rain during the growing season, and rain that comes during harvesting can speed up decay.
Farmers have a majority of their potatoes out of the ground, but the conditions have added some pressure. Harvesting should be finished by the end of June.
An average of 3 to 6 inches of rain has soaked local potato crops since Beryl passed through, he said. "I know it's too much," said local potato farmer Jeff Brubaker.
Harvesting machines are having a tougher time getting to and processing the crop because of the muddy conditions, so work is moving a bit slower, he said. He said he hopes for a break in the rain so that he can get his crop out of the ground within a week.
"The longer they sit in the water, they more chance they have to rot," Brubaker said.
Danny Johns, owner of Blue Sky Farms, said the crops have been advanced throughout the season. Heat and moisture, aided by thunderstorms that came a few weeks early, are making things worse.
"The weather is definitely starting to tell on it," Johns said.
But his farm has been lucky this week, he said. Blue Sky has only gotten about 2 1/2 inches of rain from Beryl and doesn't have any standing water. He said he has about 75 percent of his crop out of the ground.
"So far quality has been maintained," Johns said. "We've been very fortunate."
Still, there are more potatoes that have be thrown away and it is more expensive because there is more wear and tear on the equipment.
With storms looming, pressure is added.
"It kind of makes you feel like you're on borrowed time," Johns said.
Overall the season has been a good one so far, Lands said.
Every year brings with it a unique set of challenges. Though the rain is a concern, Lands doesn't think the prematurely wet conditions will prove to be a major setback in the potato fields.
"Mother nature does throw you curve balls that you have to deal with," he said.


text:
What is connecting wires called?
An electrical connector is an electromechanical device used to join electrical conductors and create an electrical circuit. Most electrical connectors have a gender – i.e. the male component, called a plug, connects to the female component, or socket.
What is it called when you connect two wires?
WHEN two electric wires are joined together, the joint formed is normally called a splice. A good splice should not only be mechanically secure, it inust also form an electrical connection which is just as efficient a conductor as the wire itself.
What is the difference between splicing and joining?
As verbs the difference between join and splice is that join is to combine more than one item into one; to put together while splice is to unite, as two ropes, or parts of a rope, by a particular manner of interweaving the strands, — the union being between two ends, or between an end and the body of a rope.
Can you fix a wire that has been cut?
If the wire has been completely cut or it's hanging on by a few strands of copper wire and you're skilled with a soldering iron you can repair the cut wire yourself. Repairing damaged wiring is easy and it can save you time and money, but care must be taken any time a soldering iron is used.
How do you twist wires together?
Twist wires together very tight. Twist connector very tight. …….Don't twist together, cover with wire connector.
- Strip stranded wire longer.
- Wrap stranded around the solid wire.
- Twist wire connector over both wires.
- Twist wire connector very tight.
- Pull stranded wire and make sure it will not come loose.
How to connect wires in 6 different ways?
Which room/s do I want wired? – I have a 2 bedroom condo so I knew I wanted both bedrooms wired.
How do you connect wires?
Starting a three-wire pigtail splice. To interlock all three wires bend each one at a right angle when you make the first twist.
How to join a wire without soldering?
Use a brazing rod to connect metal without welding. Welding is the strongest way to connect metal together,but it requires special tools and training in order to do
How to connect the wires to an outlet?
The brass screws should be connected to the Hot (line,live or phase) wire (Black,Brown or Red).


Seminar Abstract
Geoffrey Boynton
Measuring Threshold Performance in Behavioral Experiments
Time: 12:30 pm on Wednesday, February 1, 2012
Place: Savery 409
A primary tool for the experimental psychologist is the use of 'psychophysics', which is the quantitative measurement sensory experience as measured with behavioral responses. A common psychophysical measure is the 'threshold', which is the weakest stimulus needed to be reliably detected. Psychophysicists have standard methods for measuring thresholds which involves concepts and procedures including signal detection theory, maximum likelihood model fitting and bootstrapping. I will provide a general overview of the psychophysical methods for threshold measurement, hopefully in a context that a statistician might find interesting.


text:
9 STATE NORMAL SCHOOL.
animals. The design is to build up a museum that will adequately represent the natural history of Southern Utah.
LIBRARY AND READING ROOM.
The library is furnished with the standard works in literature, history, pedagogy, science and commerce, besides miscellaneous books and public documents. The best American magazines and journals, and the leading newspapers of the State are also provided.
All students have access to these from 9:00 a. m. to 5:00 p. m. on school days and at other times when necessary.
All needful provision has been made for the proper development of the body. The students have the advantage of a variety of apparatus. Through the efforts of the Athletic Association, appliances for out-door exercises, for football, baseball, basket-ball, tennis, and croquet have been provided.
MANUAL TRAINING SHOPS.
A separate workshop is fitted up for each of the three years work. These shops are provided with benches, scroll saws, lathes, forges and tools for work in wood and light metals.
The Domestic Science Department is provided with a model


text:
Why is drainage important?
When water saturated soils are stressed, either by loads being applied or the stresses exerted by an earthquake, water pressure in soils can climb drastically, thereby reducing the soil's stability.
Loading a water saturated soil can result in the water being "squeezed" out of a soil which can cause time dependent settlement issues. By installing AMPiers, this settlement can be accelerated, because the AMPiers are more permeable than the soil and allow water to escape the soil more quickly.
In an earthquake situation, AMPiers can also help the water pressure in liquefiable soils escape to the surface much faster than in untreated soil due to increased drainage properties of an AMPier.


text:
International Federation of Red Cross & Red Crescent Societies
12 July 2011, 11:05
The IFRC is developing its capacity to use mobile phone technology in the collection, management, and analysis of data. The use of the mobile phones has considerable benefits in the efficient, and reliable input, quality assurance, and timely analysis of data. Such potential is particularly well-suited for humanitarian as well as recovery settings.
With a variety or program areas, as well as 186 national societies, there are more than one example of mobile phone technology being used at the IFRC for data collection, management, and analysis. The following table summarizes some of the major software options: _URL_
Pilots have already been conducted in IFRC malaria prevention programming using Episurveyor, a nonprofit open-source software for the design and management of surveys online and enumerated through mobile phones with the use a downloaded application.
Initially, we will build upon the lessons and best practices of the use of mobile phones for data collection with household surveys (baseline/endline), triangulated with other methods to measure impact. However, there are also potential applications of the phones being used for other monitoring and assessment purposes, including needs assessment, beneficiary and context monitoring, and volunteer management.


Massacre at Kunming
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Part of a Category:Islam in China of articles on
Islam in China
Islamic Architecture in China
Chinese Mosques and Muslim Architects
Major figures
Zheng HeHaji NoorMa BufangPu Shougeng Jamal ud-Din
Muslim People in China
HuiSalarUygursKazakhsKirgiz TartarsAryan TajkisUzbeksDongxiang
Muslim Wushu Masters
Wang Zi PingMa MentaYang Wan LuChamirChang Yuchun Hu DahaiMu yingLan YuWu ZhongZhang Shao Fu
Islamic Dyansties in China
Sultanate of Xeng Hong
Yunnan SultanateFive Ma
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History of Islam in China
Ming DynastyYuan DynastyQing DynastyTang DynastyModern HistoryTimeline of Islam in China
Shuxing governing Yunnan temporarily whilst Hengchun was away, was strongly anti-Muslim. In his view, the Hui's powerful positions as merchants, caravaneers, miners, and soldiers lent them as he put it "strength far greater than their numbers".
After Hengchun left Kunming in early 1856 CE (1272 AH), a strongly anti muslim faction quickly began to take hold in Kunming. Composed of high provincial officials, including the provincial judge (fansi), the local elite, and several retired generals. This group formented a policy of attacking the Muslims in order to exterminate them. Those that opposed the factions tactics were labeled as traitors (hanjian) and were arrested.
This orchestrated violence peaked on 19th May 1856 (14th Ramadhan 1272) when Qingsheng the provincial judge, issued orders allowing "the authorized slaying of muslims without being held accountable (gesha wulun)- a directive some say was miswritten when posted to read "kill them one and all"
One chinese official described the subsequent events as follows "Then every Muslim family within the provinsial capital, regardless if they where men, or women, young or old, were all mercilessly killed" The massacre lasted three days and three nights. The cities five mosques were looted and torched. Within 72 hours as many as four thousand Muslims had been slaughtered.
The Governer Hengchun told Beijing that "if the extermination of the Hui is the only goal of the han Chinese, not only will the muslims never yield, but it will precipitate the Han Suffering.
Personal tools


text:
US Air Forces will test a landing platform on Mars in the coming months, the Air Force Space Command announced.
The landing vehicle will test the rover and lander, the command said in a statement.
The test will take place at the test site in the Mojave Desert near Redstone Arsenal, Arizona.
A landing mission is one of several NASA programs to test technologies on Mars.
NASA is also developing a spacecraft to land on Mars, called the Mars 2020 rover.
It is scheduled to launch in 2022 and then return to Earth in 2023.
The agency is expected to return the lander to the surface in 2029.
The new test will mark the third attempt to land a rover on the Red Planet.
The first test, conducted in 2003, resulted in the first landing of a rover, or a rover lander.
NASA scientists hope to land an astronaut on Mars by 2029 and then send a probe to Mars to measure the Martian surface.
NASA also hopes to send a rovers, a rover rover and a roving robot to Mars in 2037.


text:
paramagnetism n (Physics) the phenomenon exhibited by substances that have a relative permeability slightly greater than unity and a positive susceptibility. The effect is due to the alignment of unpaired spins of electrons in atoms of the material Compare →
electron paramagnetic resonance
n (Physics) another name for →
electron spin resonance (Abbrev.)
English Collins Dictionary - English Definition & Thesaurus
Add your entry in the Collaborative Dictionary.
- Create your own vocabulary list
- Contribute to the Collaborative Dictionary
- Improve and share your linguistic knowledge
"Collins English Dictionary 5th Edition first published in 2000 © HarperCollins Publishers 1979, 1986, 1991, 1994, 1998, 2000 and Collins A-Z Thesaurus 1st edition first published in 1995 © HarperCollins Publishers 1995"


text:
Weather of Arabia - The latest weather maps, resulting from the so-called computer simulation, indicate expectations of an increase in the chances of rain on the southwestern and western highlands during the month of August.
And it is expected, God willing, that the chances of rain will improve in the regions of Jizan, Asir and Al-Baha, and it will extend to parts of Makkah Al-Mukarramah and Al-Madinah Al-Munawwarah on some days, especially during the second half of the month. And despite the improvement in the chances of rain in several regions, the initial indications are that the rainfall will be less than its normal rates in many regions.
The improvement of monsoon rains comes, as a result, as a result of expectations of the deepening of what is known as the seasonal tropical belt (ITCZ) of the atmosphere of the Arabian Peninsula, accompanied by a moist air mass, and the influence of the wet monsoon winds in the middle and high layers of the atmosphere increases gradually during the month.
Arabia Weather App
Download the app to receive weather notifications and more..


UX for Stress-free Patient Facing Health Apps
Mental health was a fad in the year 2020 in India. Though the storm of social media posts gradually suppressed, the subject still deserves mainstream attention. UX is one such phenomenon that can encourage awareness and significantly impact people's mental well-being in the 21st century. From building a seamless user interface to usability testing, healthcare UX tests many skills of a designer. Building a stress-free UX is no cakewalk for a designer, but a few tips and tricks can simplify the endeavor.
We witness how our phones now come with in-built health apps that can keep track of our daily physical as well as mental well-being. Whether in-built or downloaded, these apps can have little or no impact if the functionality of the UX design is compromised. Some standard and effective design practices can allow product designers and business owners to create functional and efficient healthcare apps.
Stress is the greatest enemy of productivity. As mental health concerns like depression and anxiety are getting common in the fast-paced life, UX design stands in the spotlight to offer fast, intuitive, and effective healthcare solutions.
Facilitate interaction
They say people shouldn't hide anything from the doctor. Well, this is also true in the case of digital healthcare. While physical interaction is the best way to build a patient's trust in the treatment, UX can play a massive role in facilitating this trust through an interactive and assistive design. An intuitive and user-friendly online medical platform can contribute towards the two-way relationship between a doctor and a patient. For instance, a quick appointment, convenient checkups, discussing the diet plan or medicine plan with a trustworthy doctor will consolidate both the doctor-patient relationship and usability of the app.
Indeed trust develops dependability and lowers stress. Similarly, once a well-constructed patient app successfully cements trust, it will simplify user compliance over data-sharing. Though privacy issues become a hindrance for many people, data sharing with medical experts can certainly play a pivotal role in providing holistic treatment to patients.
Technology has made it effortless to facilitate interaction and augment a healthy relationship between doctors and patients via an assistive and user-friendly UX.
Minimalism is the key to a simple and stress-free UX.
Healthcare apps can be technical and complex for most patients. It is best to keep the UX simple and with minimal features to offer a stress-free interface. Complex detailing and sharp colors may nullify the stress-free serving of the medical platform. Soothing pastels with minimal contrast is a simple way to ease anxiety and stress for users depending on health apps. Thus, designers here should calculate the fun part of picking colors on the lines of the theme and goals of the platform for designing a stress-free app for a UX designer.
Adding smart and intuitive features like chatbots in the design result in producing an instructive and indicative health UI. Interestingly, the principle of progressive disclosure can assist designers here. Unleashing features in a gradual and informative manner eliminates confusion and provides users a stress-free feel. Similarly, a few artificial intelligence elements also enhance the utility and simplicity of the design.
Heavy jargon, complex information, intense detailing, and wrong colors may make the medical app lose the whole point of relaxing patients. Therefore designers should be minimally creative with these factors to ensure a simple, straightforward, and stress-free UX.
Don't take risks with the focus Features.
People with anxiety and stress issues may not be able to open and properly navigate the health app. Putting the most expected user questions right before the eyes as highlights of the app is the best way to optimize the genuine usability of the stress-free app. Learning to remove screen clutter and design straightforward content can help UX designers achieve their goal of making users stay on the app and solve their problems. Patients should be able to book an appointment or open medical history within a few clicks on the medical app. Determining the importance of several features and then setting them accordingly boosts the functionality of stress-free medical apps.
UX design features such as hierarchy can prioritize the features and arrange them in a profound order.
Most users do not use even 20% of the features present in the health apps. Therefore, for the sake of functionality and usability, it is vital to place the key features of the app on the main pages of the health UX.
Seamless app exploration
Once key features are set in order, exploration and easy navigation rise effortlessly in the medical app. Navigation and functionality go hand in hand; however, to design a stress-free medical app, a clear navigational guide for the users becomes the backbone of the design. Here, the classic 3 click rule can save UX designers from inventing new easy navigation ideas. 3 click rules provide any information on the digital platforms within just three simple transitions. Similar tools to employ seamless navigation in stress-free apps are navigation drawer, adding a tab bar, hamburger menu, etc.
These features can particularly save time for gathering electronic health records (EHRs) through medical apps. However, to make it effective, designers should swear to make it faster, or else the stress-free app may not stand out compared to other similar health apps.
Seamless and easy navigation should be a prominent element for a health UX to offer. Effortless navigational structures save time and increase the chances of achieving the fundamental goal of dealing with anxiety on the stress-free app.
Last but not least- Personalize
Stress can take a terrible toll on a person's mental health. UX designers should bear in mind that while they create a stress-free app, they should offer users not just technical assistance but also a trustworthy friend and guide in the form of a health app. As mentioned earlier, features like chatbots and AI elements may assist in achieving this goal. In addition to this, friendly and affirmative tones like "You did great today!", "Hydrate and stay focused!" may make patients feel connected to the medical app.
Customization can ease passive health tracking for the patients and enhance the assertiveness of stress-free health apps. Give users the liberty to set their favorite colors as the app theme colors, mute push notifications, enroll their particular health concerns, and more. Customization also gives room to accessibility and limits negative impacts of the health UX.
Customization and personalization deliver a unique or special experience to the users. Along with increasing the likability of the stress-free app, it allows patients to track health problems and solve them regularly.
A decent UX design speaks for itself when it solves user problems. Sensitive designs of healthcare apps require a safe and aesthetic vibe along with advanced interaction tools. Though this may seem arduous, a UX based on user pain points and emotions can be both interactive and assistive. Optimizing transparency and simplicity are other critical requirements of a stress-free healthcare app. UX design has the potential to eliminate barriers of technological discomfort and build a non-disruptive as well as a trustworthy health app.
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Daily Tech Term : Vocabulary
13 April, 2015
[toggle title="Drag And Drop" state="close"]Drag And Drop refers to clicking on and dragging an icon, document, image, etc. to an icon or window in order to open the item, transfer it to a new location, print it out, or delete it.[/toggle]
14 April, 2015
[toggle title="Frolleague " state="close"]A Frolleague (condensed from Friend Colleague) is a co-worker or work colleague that an individual has friended on a social network and/or become friends with outside of work.[/toggle]
17 April, 2015
[toggle title="Plesiochronous" state="close"]Plesiochronous refers to telecommunications operations that are almost synchronous.
For example, if you have a transmission exchanged between two devices with different clock settings, the transmission may not arrive in the same time slot it was sent, but if it arrives within a set/defined time range it would be considered Plesiochronous.[/toggle]


Hexachlorobutadiene
From Coastal Wiki
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Definition of hexachlorobutadiene (HCBD):
Hexachlorobutadiene, also known as perchlorobutadiene, is a colourless liquid and has a turpentine-like odour. [1]
This is the common definition for hexachlorobutadiene (HCBD), other definitions can be discussed in the article
Notes
Hexachlorobutadiene
Hexachlorobutadiene
Formula
C4Cl6
Historically HCBD was used as a solvent for rubber and other polymers, heat transfer fluids, transformer liquid and washing liquor for removing hydrocarbons. It has also been used in agriculture as a seed dressing and fungicide for a variety of crops. Due to environmental concerns the use of HCBD in such applications has now virtually ceased, although it is possible that HCBD may still be in use in some parts of the world. HCBD is still generated as a by-product of tetrachlorethene and tetrachloromethane production. HCBD mainly enters the environment during processing: in 1997 EU countries emitted 2 kg of HCBD into the atmosphere and 100 kg into the hydrosphere[2].
Hexachlorobutadiene has quite a high vapour pressure and is therefore mainly present into the atmosphere (98%), where it has a half-life between 60 days and 1 year. In water it has a low solubility of 3,2 mg/l and has a tendency to adsorb to suspended particles and sediments. In fact only 0,2 percent of the environmental HCBD is expected to be dissolved in water and the remaining 1,8% adsorbed to sediments and soils. In aerobic waters and soils, HCBD can be biodegraded, although its half-life in water is between 30 and 300 days[1].
Hexachlorobutadiene has a high potential to bioaccumulate. High bioaccumulation rates have been shown in a number of marine species, although in others hardly any bioaccumulation took place. Some species appear to be more able to metabolise HCBD than others[1]. Fish seem to accumulate high levels in their livers, about 10 times more than in other tissues. HCBD seems to have a lower tendency to bioaccumulate through food uptake than through direct uptake from water. One study which fed predatory fish with contaminated prey fish in fact demonstrated lower concentrations in the predatory fish. A study where rats were fed with contaminated food also didn't demonstrate any bioaccumulation. Therefore the risks of secondary poisoning for marine mammals and sea birds by biomagnification are doubtful[2].
Acute toxicity in marine fishes can be caused by concentrations above 0,45 mg/l, in algae by concentrations above 0,85 mg/l. Birds fed during 90 days with food containing 10 mg/kg HCBD displayed a reduced fertility, caused by a reduced chick survival[2].
Measured marine surface water concentrations of HCBD in Europe have reached values of up to 150 ng/l in polluted estuaries, although typical North Sea concentrations are around 4 ng/l. The highest concentration measured in fish tissue was 0,4 µg/kg[2].
Environmental standards and legislation
Included in the water framework list of priority substances
References
 1. 1.0 1.1 1.2 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES 1994 TOXICOLOGICAL PROFILE FOR HEXACHLOROBUTADIENE
 2. 2.0 2.1 2.2 2.3 Euro Chlor 2002 Euro Chlor Risk Assessment for the Marine Environment OSPARCOM Region - North Sea Hexachlorobutadiene
The main author of this article is Daphnis De Pooter
Please note that others may also have edited the contents of this article.
Citation: Daphnis De Pooter (2013): Hexachlorobutadiene. Available from _URL_ [accessed on 13-12-2017]


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Math Prerequisites for Taking a Data Science Course
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Embarking on the journey of data science requires a solid mathematical foundation. Mathematics is the backbone of data science, providing the tools and frameworks needed to analyze data, develop algorithms, and make informed decisions. Understanding the math prerequisites for those considering a data science course in Pune is crucial to ensure a smooth and successful learning experience.
Importance of Mathematics in Data Science
Mathematics is pivotal in data science, underpinning many of the concepts and techniques used in the field. From statistical analysis to machine learning algorithms, math is integral to understanding and solving complex data problems. Enrolling in a data science course in Pune will expose students to various mathematical concepts, making it essential to fully grasp some mathematical regions before starting the course.
Algebra and Linear Algebra
One of the fundamental areas of mathematics required for data science is algebra, particularly linear algebra. Linear algebra studies vectors, vector spaces, and linear transformations, crucial for understanding data structures and algorithms in data science. Matrices, eigenvalues, and eigenvectors are helpful in machine learning algorithms and data processing techniques.
A profound understanding of linear algebra is essential for those planning a data science course in Pune. Many data science algorithms rely heavily on linear algebra, including principal component analysis (PCA) and singular value decomposition (SVD). Therefore, familiarity with these concepts will provide a strong foundation for the advanced topics covered in the course.
Calculus
Calculus is another crucial prerequisite for a data science course, particularly differential and integral calculus. Calculus optimises algorithms, understands variable changes, and models continuous data. In data science, calculus applies to developing and optimising machine learning models.
In a data scientist course, students will encounter calculus in various forms, such as gradient descent algorithms used for training models. A good grasp of derivatives, integrals, and multivariable calculus will help students understand how these algorithms work and how to implement them effectively.
Probability and Statistics
Probability and statistics are the most crucial areas of mathematics for data science. These fields provide the foundation for making inferences about data, understanding distributions, and evaluating the uncertainty of outcomes. Concepts such as statistical significance, probability distributions, hypothesis testing, and Bayesian inference are central to data science.
Enrolling in a data scientist course will require a thorough understanding of probability and statistics. These concepts help interpret data, validate models, and ensure the reliability of results. For instance, understanding statistical significance is vital when determining whether a model's predictions are genuinely helpful or simply due to random chance.
Discrete Mathematics
Discrete mathematics deals with structures that are fundamentally discrete rather than continuous. It includes topics like combinatorics, graph theory, and logic, all relevant to data science. Discrete mathematics is essential for understanding algorithms, data structures, and the theoretical underpinnings of computer science.
Students taking a data scientist course will benefit from the knowledge of discrete mathematics, mainly when working with algorithms and complex data structures. This background will help design and analyze efficient and practical algorithms for large datasets.
Numerical Methods
Numerical methods involve techniques to approximate mathematical operations and solve mathematical problems numerically. These methods are crucial for implementing data science algorithms that could be more solvable analytically. Topics such as numerical integration, root-finding algorithms, and solving differential equations numerically are essential for practical data science applications.
In a data scientist course, students will likely encounter numerical methods when working with large datasets and complex models. Understanding these methods is crucial for effectively implementing algorithms and ensuring accurate results.
Real-World Applications and Problem-Solving
Beyond the theoretical aspects, applying mathematical concepts to real-world problems is a critical component of data science. Translating mathematical theory into practical solutions differentiates influential data scientists. A data science course in Pune will emphasise practical applications, requiring students to apply their mathematical knowledge to solve real data problems.
Preparing for a Data Science Course
Assessing and strengthening mathematical skills is essential for those planning to enroll in a data science course. Preparatory courses in linear algebra, calculus, probability, statistics, and discrete mathematics can provide a strong foundation. Additionally, practicing problem-solving and applying these concepts to data-related problems will enhance your readiness for the course.
Online resources, textbooks, and preparatory classes can be valuable tools for building your math skills. By ensuring you have a solid mathematical foundation, you will be better equipped to tackle the challenges and complexities of data science.
Conclusion
Mathematics is an indispensable part of data science, and a solid mathematical foundation is crucial for anyone considering a data science course in Pune. Understanding algebra, calculus, probability, statistics, discrete mathematics, and numerical methods will provide the necessary tools to succeed in the field. By preparing in these areas, aspiring data scientists can ensure they are well equipped to understand and apply the advanced concepts and techniques they will encounter in their studies and future careers.
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OBJECTIVE: To investigate a new wide bone-anchored hearing implant considering initial stability, stability over time, implant loss, and skin reaction. STUDY DESIGN: Consecutive, prospective case series. SETTING: Tertiary referral center. PATIENTS: Twenty adult patients were enrolled. All operations were 1-stage, single-incision technique with subcutaneous reduction. INTERVENTION(S): Measurement of implant stability. MAIN OUTCOME MEASURE(S): Implant stability quotient (ISQ) values were recorded using resonance frequency analysis at the time of implantation and at 10 days, 6 weeks, 6 months, and 1 year after surgery. Skin and soft tissue reactions according to Holgers grading system. RESULTS: Implant stability quotient measurements revealed a significant increase in ISQ during the first 10 days after operation, and the ISQ values continued to rise throughout the 1-year observation period. No implants were lost. Skin and soft tissue reactions were rare and minor, as no reaction was seen in 93% of the follow-up examinations and no grade 4 reactions occurred. CONCLUSION: The new wide implant showed good stability at surgery. Osseointegration was fast, and implant stability increased throughout the 1-year observation period. No implants were lost. Skin and soft tissue reactions were rare and minor.
Otology and Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2014, Vol 35, Issue 7, p. 1238-41


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Some Aspects of Stock Plant Management
For a nursery to have a good stock of mother plants is like having money in the bank. An asset of guaranteed vegetative stock material gives assurance, for on-going production and continuity of supply to customers. A wide range of stock plants gives production a choice of diversity, flexibility, and peace of mind for planning ahead, and also allows the luxury of variety and change.
To yield high quality propagation material however, the mother plants have to be managed correctly to give best results, if mismanaged or neglected the mother plants can quickly become a valueless liability. At Duncan and Davies, depending on genera and species, our mother plants generally can be divided into four basic groups:
- In-ground, longer-term, permanent stock, planted out in stock bed rows.
- In-ground, short-term, nursery row, temporary stock.
- Containerised temporary stock:
- From saleable potted crops where conformation trimming can yield useful cutting material or
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text: The progam mkjobtexmf runs a program and tries to find the used file names. Two methods are available, option "-recorder" of TeX (Web2C) or the program strace. Then it generates a directory with a texmf tree. It checks the found files and tries sort them in this texmf tree. It can be used for archiving purposes or to speed up following TeX runs.


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Argulus foliaceus is a freshwater fish ectoparasite that has been reported throughout temperate regions of Europe, Central Asia, and North America. It has been well studied in Europe, especially the British Isles, where is has had major impacts on UK sport fisheries through fish stress and mortality. (Harrison, et al., 2006; Oktener, et al., 2007; Pasternak, et al., 2004)
Argulus foliaceus is found in warm, eutrophic, still lakes of both fresh and brackish water. Eggs are laid in shady areas, rather than in direct sunlight. Typically considered a shallow water species, this louse is often observed laying eggs within the top 1 m of the water column (although it will lay eggs in deeper water at the end of the reproductive season). Argulus foliaceus is an obligate parasite, requiring host availability. This louse has a low host specificity, so it can infect a variety of fish within its habitat. (Harrison, et al., 2006; Pasternak, et al., 2000; Taylor, et al., 2006)
On average, Argulus foliaceus measures a total length of 3-7 mm and a width of 2.5-5 mm. Argulid females are generally larger than males, and the growth of the parasite may be influenced by the size of the host. A distinguishing characteristic of A. foliaceus is the urosome, consisting of rounded lobes that are covered marginally with small spines. The posterior incisures of the urosome do not reach to the center. Another characteristic is the anterior portion of the cephalothorax that forms a broad protrusion with shallow grooves. Adults use suction discs for host attachment, whereas larvae utilize larval hooks. (Moller, et al., 2008; Oktener, et al., 2007; Pasternak, et al., 2004)
Argulus foliaceus larvae are free-swimming. The length of the larval phase is highly variable, most likely influenced by temperature. In general, larvae are typically first observed in the late spring and morph into adults in the fall. Argulus foliaceus is exceedingly rare in the winter. Larval development is divided into two distinct morphological phases: stage I as a metanauplius and stage two as a juvenile. While morphological adaptations do appear in stage I larvae, there is currently no conclusive evidence that the stage I larvae are either parasitic or pelagic, so they are typically considered "semi-pelagic." (Moller, et al., 2007; Pasternak, et al., 2000)
A female A. foliaceus leaves the host fish to lay its eggs, but as an obligate parasite, it must return to a host fish occasionally throughout the process. There is variability in the frequency and length of time that the female leaves and returns to the host. Because females are dependent on the host fish while laying eggs, the individual vulnerability and population density of fish can influence this louse's reproductive success and survivorship. While A. foliaceus is commonly believed to be a shallow water species because it is most often observed to lay eggs in the top 1 m of the water column, some studies have indicated that, if available, they prefer deeper water (8.5 m) at the end of the egg-laying season. The suggestion that they lay eggs in shallow water may be a bias due to study sites. Temperature and dissolved oxygen content may influence egg laying depths, but there is currently no conclusive evidence for these trends. Eggs are laid in strings or clutches that contain an average of 100-150 eggs, but there can be as few as four or as many as 250 eggs. The female lays her eggs in the winter, but there is a wide variability in hatching time, possibly due to fish availability. (Harrison, et al., 2006; Pasternak, et al., 2000)
There is no information about parental investment in Argulus foliaceus reported in the literature.
Argulus foliaceus is rare in the winter and has been described as having a short lifespan. There is no information reported in the literature, however, on the actual length of its lifespan. (Dzika, 2002; Pasternak, et al., 2000)
Argulus foliaceus most commonly attaches to the host on the skin epithelium of the body and fins, but has been observed to also attach to the gills. This louse feeds by piercing the host skin, injecting a toxin, and drawing blood. Infection of A. foliaceus often results in host tissue damage and sometimes mortality. Argulus foliaceus infects irrespective of the health of the host. The length of residence time on the host between attachment to detachment is quite variable. In general, ectoparasites aggregate on the host so that few individuals within the host population are actually infected. The aggregation is likely due to host behavior; when stressed, the host's movement is reduced, allowing more parasites to attach. (Bandilla, et al., 2005; Nolan, et al., 2000; Oktener, et al., 2006; Pasternak, et al., 2004)
There is no information on the home range of Argulus foliaceus reported in the literature.
Adult argulids can respond to some chemical cues. They have higher sensory abilities, swimming abilities, and metabolism than juveniles, so the adults are less dependent on host attachment, allowing them to leave one host in search for another of higher preference. At the individual level, the searching abilities of Argulus foliaceus are limited, so changes at the population level, such as host preference and aggregation, are necessary to increase reproductive success and survivorship, in light of unpredictable host availability. (Bandilla, et al., 2005; Pasternak, et al., 2000)
Argulus foliaceus is an obligate bloodsucker, and it cannot survive more than few days without a host. Having little specificity for hosts, it infects a wide range of species. (Pasternak, et al., 2000)
Argulus foliaceus is often noted for its role in ecosystems as an ectoparasite. With a low host specificity, it has been found on almost every type of freshwater fish within its natural habitat, yet some fish are more susceptible than others. Argulus foliaceus has been reported on fish in the families Cyprinidae, Salmonidae, Gobiidae, Gasterosteidae, and Acipenseridae, as well as amphibians, including frogs and toads (Anura). In fish farms of Central Finland, it was found to coexist with Argulus coregoni, a closely related ectoparasite. In addition to its function in ecosystems as a parasite, A. foliaceus can also be a vector for bacteria and flagellates, and it serves as an intermediate host of nematodes in the family Skrjabillanidae. (Oktener, et al., 2006; Pasternak, et al., 2004; Walker, et al., 2007)
There are no known positive effects of Argulus foliaceus on humans.
While Argulus foliaceus is frequently found in small numbers with little damage to the hosts, epizootics may occur. When infected by A. foliaceus, host fish display an increase in jumping behavior and a decrease in feeding, followed by secondary bacterial and fungal infections, shoaling behavior, and finally, possible large-scale mortality. Argulus foliaceus infections have been reported to wipe out trout stock populations and cause problems in carp farming. In sport fisheries, a common issue is not mortality but rather reduced catch and lowered aesthetic appeal, resulting in economic losses. (Cross and Stott, 1974; Nolan, et al., 2000; Taylor, et al., 2006)
Argulus foliaceus is a mechanical vector of the spring viraemia of carp (SVC), an acute viral disease in Cyprinus carpio, transferring the virus from infected to non-infected individuals. (Ahne, 1985)
Jessica Kafer (author), The College of New Jersey, Keith Pecor (editor), The College of New Jersey, Renee Mulcrone (editor), Special Projects.
living in the Nearctic biogeographic province, the northern part of the New World. This includes Greenland, the Canadian Arctic islands, and all of the North American as far south as the highlands of central Mexico.
living in the northern part of the Old World. In otherwords, Europe and Asia and northern Africa.
having body symmetry such that the animal can be divided in one plane into two mirror-image halves. Animals with bilateral symmetry have dorsal and ventral sides, as well as anterior and posterior ends. Synapomorphy of the Bilateria.
areas with salty water, usually in coastal marshes and estuaries.
an animal that mainly eats meat
uses smells or other chemicals to communicate
animals which must use heat acquired from the environment and behavioral adaptations to regulate body temperature
mainly lives in water that is not salty.
having a body temperature that fluctuates with that of the immediate environment; having no mechanism or a poorly developed mechanism for regulating internal body temperature.
A large change in the shape or structure of an animal that happens as the animal grows. In insects, "in


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How to calculate unit weight of steel bar ? By Afroz Civil Summary D ia. of bar in mm Weight of bar in Kg 6mm 0.222Kg 8mm 0.395 Kg 10mm 0.616 Kg 12mm 0.888 Kg 16mm 1.578 Kg 20mm 2.466 Kg 25mm 3.853 Kg 32mm 6.313 Kg 40mm 9.865 Kg Formula for calculate Weight of steel bar per metre length. *Weight =(Diameter of steel bar ) 2 /162 Kg/m * Here , Explanation ◆ What is Steel? Steel is the most versatile commonly used structural material. The essential elements in steel are metallic iron and the element non-metallic carbon, with small quantities of other elements such as silicon, nickel, manganese, chromium and copper. It is thus an alloy. Though steel is usuall
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The role of CpG islands hypomethylation and abnormal expression of neuronal protein synuclein-gamma (SNCG) in ovarian cancer.
BACKGROUND: The synucleins are a family of small cytoplasmic proteins that are expressed predominantly in neurons. Recently, their expression has been found also in many human cancers.
AIM: To understand the molecular mechanisms underlying the abnormal expression of SNCG in malignant ovarian tumors, in this study, we examined the methylation status of a CpG island located in exon 1 of SNCG gene in a panel of ovarian malignant tumors to determine if DNA methylation is related to clinical and histological tumor characteristics.
METHODS: SNCG mRNA expression in tumor samples was assessed by RT-PCR. Methylation status of SNCG gene was studied using methylation specific PCR (MSP).
RESULTS: Study group included 43 ovarian carcinoma samples (40 primary and 3 metastatic). The expression of SNCG mRNA was detectable in 33 of 43 ovarian cancer cases (76.7%). There were no significant differences in the mRNA expression between serous or nonserous tumors. The presence of SNCG mRNA in tumor samples was not correlated with age and menopausal status of patients, also no correlation was found with clinical stage or histological grading of malignant tumors. In 29 of 43 (67.4%) cases of tumors unmethylated product of MSP amplification was present. In a group of SNCG mRNA-positive tumors there were 75.7% (25 of 33) cases with demethylated or hypomethylated exon 1 of SNCG. The differences between the groups were statistically significant (chi2 =4.46; p=0.034). Demethylation of SNCG was not related to clinical tumor stage (p>0.05), but it was strongly associated with tumor grading (chi2=6.66; p=0.035). Aberrant methylation of SNCG was more often seen in tumors of women after menopause (78.2% vs 55%). In postmenopausal women 18 of 33 (62.1%) tumor samples synuclein-gamma mRNA expression was found, however the differences were not statistically significant. No correlations between SNCG hypomethylation and patient age, clinical stage and tumor grading were found. In 9 of 43 samples (21%) both products of amplification with methylated or unmethylated primer sets were found. In all of these cases SNCG mRNA was present.
CONCLUSIONS: SNCG mRNA is expressed in a substantial proportion of malignant ovarian tumors and demethylation is an important event in abnormal synuclein-gamma expression in most of these cases....