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CancerMine
The CancerMine resource is a text-mined knowledgebase of drivers, oncogenes and tumor suppressors in cancer. Abstracts from PubMed and full-text articles from PubMed Central Open Access subset and Author Manuscript Collections are processed to find references to genes as drivers, oncogenes and tumor suppressors in different cancer types.
CancerMine is an automatically updated dataset. You can navigate the data using the web viewer or you can download the latest data from Zenodo (or through the web viewer). You likely would not have to run any of the code in this repository.
System Requirements
This is a Python3 project which has been tested on Centos 6/7 but should work on other Linux operating systems and MacOS. An individual process of this can be run on a laptop or desktop computer. But in order to process all of the literature (PubMed, etc), this should really be run on a cluster or server-like machine. A cluster that uses Slurm or the SunGrid engine (SGE) are supported. Each node needs only 4 GBs on RAM.
This project relies on text mining using Kindred and Snakemake. These can be installed through pip.
It uses biomedical text converted using BioText.
Installation Guide
You can clone this repo using Git or download the ZIP file of it.
git clone _URL_
It uses the BioText project which downloads and converts the biomedical research literature into the BioC XML format. You'll need to clone it and run the conversion scripts.
The code dependencies can be installed with the command below. Remember to install the English language model for Spacy.
pip install kindred snakemake zenodo_get
python -m spacy download en
Installation should take a maximum of 15 minutes (mostly due to the Spacy and language models installation).
Demo
We include example input and the expected output data for a small test run in the exampledata/ directory. To run a small test run of the scripts you can follow the steps below. Alternatively, all these commands are in the demoRun.sh file which can be executed independently (after installing dependencies). This file is run during the TravisCI test. This should only take six minutes.
First you need to build the machine learning models. This will extract the training data and build the necessary models from it.
sh buildModelsIfNeeded.sh
Then you need to process the input wordlists to get them ready for quick access. This generates various data structures that are stored in a Python pickle.
python wordlistLoader.py --genes exampledata/mini_terms_genes.tsv --cancers exampledata/mini_terms_cancers.tsv --drugs exampledata/mini_terms_drugs.tsv --conflicting exampledata/mini_terms_conflicting.tsv --wordlistPickle exampledata/mini_terms.pickle
There is a small test input file (examples/test.bioc.xml). It's in BioC XML format which is a format for biomedical corpora. You can run the relation extraction process with the commands below. There are also mini wordlists for test usage which are tiny subsets of the BioWordlists project project used for this.
# Find sentences that contain cancer types and gene names and filter using the terms in the filterTerms.txt
python parseAndFindEntities.py --biocFile exampledata/input.bioc.xml --filterTerms filterTerms.txt --wordlistPickle exampledata/mini_terms.pickle --outSentencesFilename exampledata/intermediate_sentences.json
# Apply the machine learning models to identify actual mentions of drivers, oncogenes and tumor suppressors
python applyModelsToSentences.py --models models/cancermine.driver.model,models/cancermine.oncogene.model,models/cancermine.tumorsuppressor.model --filterTerms filterTerms.txt --wordlistPickle exampledata/mini_terms.pickle --genes exampledata/mini_terms_genes.tsv --cancerTypes exampledata/mini_terms_cancers.tsv --sentenceFile exampledata/intermediate_sentences.json --outData exampledata/intermediate_relations.tsv
# Add the header to this file
cat header.tsv exampledata/intermediate_relations.tsv > exampledata/out_unfiltered.tsv
And then you can run the filter and collate process using the command below on that.
python filterAndCollate.py --inUnfiltered exampledata/out_unfiltered.tsv --outCollated exampledata/out_collated.tsv --outSentences exampledata/out_sentences.tsv
Instructions for use
To run the full thing, you should use Snakemake. It manages the download of all the inputs outlined below. But first, you should do a test run (which should only last a minute or so):
MODE=test snakemake --cores 1
Then to do the full run which may take a long time, run the following and set the path to the BIOTEXT directory accordingly:
MODE=full BIOTEXT=$BIOTEXT snakemake --cores 1
Practically, you'll likely want to use a cluster to parallelize this. Please refer to the Snakemake documentation for information about how to use a cluster.
For uploading the output to Zenodo, this project uses bigzenodo and the submission.json file.
It is not possible to exactly reproduce the results as the data in PubMed and PMC are constantly being added to. The data used in the paper is downloadable from Zenodo with the Jun 30th 2018 release.
Inputs
The text inputs for processing are:
The text is scanned for references of genes and cancer types. These are based on HUGO gene names and cancer types from the Disease Ontology. These are managed through the BioWordlists project which can be downloaded at _URL_
The training data used to build the machine learning models can be found at data/cancermine_corpus.zip. This is stored in BioNLP Shared Task format and has one file per sentence. The raw annotations from the three annotators can be found at data/raw_annotations
Outputs
There are three final results files from CancerMine. These are hosted on Zenodo and can also be downloaded through the web viewer. Each file is a tab-delimited file with a header, no comments and no quoting.
You likely want cancermine_collated.tsv if you just want the list of cancer gene roles. If you want the supporting sentences, look at cancermine_sentences.tsv. You can use the matching_id column to connect the two files. If you want to dig further and are okay with a higher false positive rate, look at cancermine_unfiltered.tsv.
cancermine_collated.tsv: This contains the cancer gene roles with citation counts supporting them. It contains the normalized cancer and gene names along with IDs for HUGO, Entrez Gene and the Disease Ontology.
cancermine_sentences.tsv: This contains the supporting sentences for the cancer gene roles in the collated file. Each row is a single supporting sentence for one cancer gene role. This file contains information on the source publication (e.g. journal, publication date, etc), the actual sentence and the cancer gene role extracted.
cancermine_unfiltered.tsv: This is the raw output of the applyModelsToSentences.py script across all of PubMed, Pubmed Central Open Access and PubMed Central Author Manuscript Collection. It contains every predicted relation with a prediction score above 0.5. So this may contain many false positives. Each row contain information on the publication (e.g. journal, publication date, etc) along with the sentence and the specific cancer gene role extracted (with HUGO, Entrez Gene and Disease Ontology IDs). This file is further processed to create the other two.
Shiny App
The code in shiny/ is the Shiny code used for the web viewer. If it is helpful, please use the code for your own projects. The list of dependencies is found at the top of the app.R file.
Explanation and Pseudocode
The associated pseudocode.md file contains detailed information about the purpose of the various scripts here.
Paper
The code to generate all the figures and text for the paper can be found in paper/. This may be useful for generating an up-to-date version of the plots for a newer version of CancerMine.
Changelog
 - v11 data release: change to Kindred's EntityRecognizer uses strict string matching instead of token matching, so results are minorly different
 - v29 data release: WARNING - this release contained buggy data and missed publications in the Author Manuscript Collection. This was after a conversion from PubRunner to BioText


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text:
- November 15th, 2008
- Derek Robertson
- Comments: 7 Comments »Tags: Consolarium, Endless Ocean, games based learning, Wii
Endless Ocean for the Nintendo Wii was one of those games that immediately caught my eye. A wonderful world in which the player can become immersed in a rich, vibrant and somewhat hypnotically therapeutic underwater world. I've written about how I thought it might be used to drive learning before but my initial ideas have been put into place and extended beyond recognition by some really creative teachers.
Last week I went with Margaret Cassidy from Stirling Council to Cowie PS to see a teacher that was using Endless Ocean with her class:
Mrs Bullivant and her class of P.6 children treated me to an afternoon of sheer joy. I walked in to a class that had been turned into an underwater world that was awash with a tide of enthusiastic and industrious learnning.
- Streamers of various shades of blue were hung from two lines that criss-crossed the class.From these lines also hung starfish, sharks and other underwater creatures that the children had made.
- The Wii was hooked up to the whiteboard and the gameplay was integral to the learning.
- The children were divided into 'dive teams' and their 'dive leader' had to manage certain aspects of how the children worked together.
- Children were engaged with a teacher led leson that investigated buoyancy.
- Children were searching the web to find out more about some of the creatures that they discovered in the game.
- A spreadsheet activity detailing the range of creatures that they had discovered was in place.
- A shipwreck (created by the janitor) was sitting in the class. This helped drive much of the creative writing work.
- The children created treasure maps and were using these to look at grid references.
- Mermaids were created in art and design and very lifelike they were too!
- Reference books were in great demand when I was in the class and the initial stimulus of the game appeared to drive a real interest for what could be found in the complementary resource that was the book.
- Children actively encouraged to measure exactly how long 7 metres is as a result of finding out that that was how long a Great White Shark was.
This was just a wonderful visit and an example of what learning in class can be. Yes we need creative teachers to lead this but isn't that what we are meant to be. The work that was in evidence in this class was delightful to witness and further cemented my ideas of the possibilities of sandbox games such as Endless Ocean.
Categories Stirling Council

source: HuggingFaceFW/fineweb-edu


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Pharmacy inspections
Inspection reports and learning from inspections
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Cranston Ltd (_PHONE_)
Inspection outcome: Standards met
Last inspection: 14/10/2019
Pharmacy context
This is a community pharmacy set next to a medical practice in Thornton Heath. The pharmacy opens five days a week. And most people who use it are patients of the medical practice. It sells a range of over-the-counter medicines and dispenses NHS and private prescriptions. It provides multi-compartment compliance packs to help people take their medicines. And it offers winter influenza (flu) vaccinations and a paid-for travel clinic.
Inspection summary findings
Principle 1. Governance
Standards met
The pharmacy has written procedures to help make sure its team works safely. It continually monitors the safety of its services to protect people and further improve patient safety. Its team members log and review the mistakes they make. So, they can learn from these and act to avoid problems being repeated. The pharmacy has appropriate insurance to protect people if things do go wrong. It mostly keeps all the records it needs to by law. And it asks people using its services for their views. People who work in the pharmacy can explain what they do, what they're responsible for and when they might seek help. They work to professional standards and identify and manage risks appropriately. They understand their role in protecting vulnerable people. And they keep people's private information safe.
Principle 2. Staff
Good practice
The pharmacy has enough suitably qualified team members to provide its services safely and effectively. And it encourages its team members to give feedback. Staff work well together as a team and have a work culture of openness, honesty and learning. And they learn from their own and other people's mistakes. The pharmacy team makes appropriate decisions about what is right for the people it cares for. Staff know how to raise a concern if they have one. And their professional judgement and patient safety are not affected by targets.
Principle 3. Premises
Standards met
The pharmacy provides a secure and professional environment for people to receive healthcare. It has a room where people can have private conversations with members of the pharmacy team.
Principle 4. Services, including medicines management
Standards met
The pharmacy's working practices are safe and effective. The pharmacy helps people access its services. It gets its medicines from reputable sources and it stores them appropriately and securely. Its team usually disposes of people's waste medicines safely too. The pharmacy's team members check stocks of medicines to make sure they are fit for purpose. And they make sure people have the information they need to take their medicines safely.
Principle 5. Equipment and facilities
Standards met
The pharmacy has the right equipment and facilities to provide its services safely. It uses these to keep people's private information safe.
Pharmacy details
951 London Road
Find nearby pharmacies
What do the inspection outcomes mean?
Met The pharmacy has met all the standards for registered pharmacies
What do the summary findings for each principle mean?
Standards met The pharmacy meets all the standards


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Is there a way to let a line, polygon,..., looks like it has been scribbled or hand drawn?

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Sure, break the line into several lines (or use a path with as many segments as you want). It should be fairly trivial to write a script that adds a bit of randomness to the points in each path segment. Another way is to use svg filters, see this example (more context and further examples available here).
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text:
C-TRAN has used Bus on Shoulder lanes since they were first implemented in Clark County in 2017. The concept allows transit vehicles to use the shoulder of a given corridor to bypass traffic during times of heavy congestion. It creates faster travel times for buses and more reliable transit service for our region's commuters.
There are limitations:
- For a bus to use the shoulder, the overall speed of traffic must be less than 35 mph.
- While using the shoulder, buses are only allowed to go up to 15 mph faster than other traffic, to a maximum speed of 35 mph.
- Priority for shoulder use is always given to emergency vehicles, stalls or breakdowns.
Bus-only shoulder lanes are currently in use on three freeway corridors in the region: State Route 14, Interstate 5 and Interstate 205.
State Route 14
Location: SR 14 between SE 164th Avenue and Interstate 205, Vancouver
Direction: Eastbound and westbound
Primary C-TRAN routes on corridor: 41, 65, 67, 164
Location: I-5 between 99th Street and the Interstate Bridge, Vancouver
Primary C-TRAN routes on corridor: 105, 134, 157, 199
Location: I-205 across the Glenn Jackson Bridge, Vancouver/Portland
Direction: Northbound and southbound
Primary C-TRAN routes on corridor: 65, 67, 164, 177

source: openbmb/Ultra-FineWeb


text:
The Gordon MacMillan Southam Observatory in Vancouver provides a window into space through its 1/2 metre Cassegrain telescope.
After the completion of the nearby H.R. MacMillan Space Centre in 1968, the Gordon MacMillan Southam Observatory was built in 1979 to explore the night sky and aids in the research of interesting phenomenon, studying of the moon and even the sun.
Inside its 10 metre diameter and hemispherical dome, the Gordon MacMillan Southam Observatory features a 1/2 metre Cassegrain telescope (more specifically, the telescope is a 1/2 metre, f/16 classical Cassegrain reflector telescope on a fork-style equatorial mount, and equipped with a 15cm f/15 refractor guidescope [telescope diagram]) which is fully computer controlled and is used for research and to educate the public.
Every clear Saturday evening from 8:00pm and well into the night, visitors can step into the shoes of an astronomer and check out the inside of this futuristic observatory. Computers, TV monitors and the Observatory's star attraction, its telescope, provides a look into the operations of the building and the work being done there. Staff and volunteers are on hand to answer questions and help identify what visitors are looking at through the telescope or just to talk about celestial events and other night sky phenomenon.
Open year round, the Gordon MacMillan Southam Observatory is the perfect place to spend an evening learning about the night sky. Don't miss the opportunity to take a peek into outer space every Friday and Saturday evening!
Use the interactive map below to locate and explore the areas around Gordon MacMillan Southam Observatory - Vancouver, British ColumbiaBeside the H.R. MacMillan Space Centre at 1100 Chestnut Street
Click the brown GEMS on the map to navigate to the other activities within this region

source: m-a-p/FineFineWeb


text:
How 2 find cube root using excel
To get the cube root of a number, you can use the caret(^) operator with 1/3 as the exponent in a simple formula. In the example shown, the formula in C5 is. Open an Excel file; Let's find the square root of a number; Here the number is ; The formula is; Square root formula=POWER(E3,1/2). When we use the. How to find square, cube, and nth roots in Excel using exponents and functions in formulas, with a step by step example included.
The trick is to realize that finding the cube root is the same as raising a So you find a cube root of the number in cell A1 using a formula like. For a Microsoft Excel 97 and earlier version of this article, see This step -by-step article shows you how to find the nth root of a number. Hi Does anyone know how to perform the cube root function in excel? By the way I did do a search for cube root & got The best way to search for Excel issues is to download Ron de Bruin's add-in for searching newsgroup.
A2^(1/3) tbh_29 wrote: > Any one know how i can do cube roots on excel? i know square To get replies by our experts at nominal charges, follow this link to buy points and The lookup functions should have an optional argument for the return In addition to A1^(1/3) you can use =POWER(A1, 1/3). #2. Calculate SQUARE Root of a Number Using POWER Function Apart from the square root, we can use it to calculate cube root or any nth.
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text:
EIGHT LEADING-EDGE FOOD TREND PREDICTIONS FOR 2021-2022
Originally published in Oct 2019 (view) and now updated to account for COVID-19.
International Food Trendologist, Liz Moskow teamed up with food innovation intelligence platform Spoonshot to predict and interpret the food trends that will impact menus, product development, and consumer behavior into 2021.
By leveraging Spoonshot's massive data pool that processes millions of inputs daily, Liz Moskow predicts trends before they happen, rather than highlighting them after trend adoption has begun.
Spoonshot analyzes billions of data points, across 22 different types of data, spanning more than 12K long-tail data sources. These include scientific journals, niche food communities, and social commerce platforms. Spoonshot connects seemingly disparate dots between these data sets using AI and food science domain expertise to uncover innovation opportunities.
Given the huge volume of data examined and algorithmic connections made, Liz Moskow can predict and interpret food trends empowered with new levels of organic intelligence.
Welcome to the future of food – Food Trends 2021
These eight leading-edge food trend predictions for 2021 are a result of this partnership. We've now updated them keeping in mind the impact COVID-19 will likely have on them. Seven of the eight initial trends made the cut, and we've replaced the one trend that didn't make it.
The vilification of sugar is real! With continued mounting pressure from consumers to reduce product sugar content, CPG companies are rushing to find a new gold standard of sweetness.
Both changes in FDA labeling requirements and food technology advancements are paving a path for two new approaches to sweetening. Sugar replacer, allulose is about to trend. Riding on the heels of the FDA's decision to exclude allulose, a sweetener derived from wheat and certain fruits from the total and added sugar declarations on nutritional facts panels, allulose is alluring to product developers.
Taking a food tech approach, Nestlé and DouxMatok are focused on maximizing the efficiency of sugar to provide products with the same perceived sweetness but by using up to 40% less of it.
Look for both allulose and sugar reduction technologies to trend into 2021 and beyond.
The pandemic completely knocked us off track in terms of healthy eating and living in its initial months. Inconsistent routines, lower activity levels, and stress saw consumers gravitate to comfort food and reap the consequences of this shift in behaviour. Over 3 in 4 Americans surveyed said they gained up to 16 pounds in isolation.
Now, however, most of them are re-prioritizing improving their diets, which will include cutting down on sugar. This will also drive the demand for sugar substitutes and new technologies in the sugar reduction space.
Allulose has started to expand into multiple formats – crystal form and liquid syrup – and is making its presence felt in multiple categories as a sugar substitute. Replacement products featuring a combination of allulose and sucralose as sweeteners will become more common. Meal replacement brand Soylent, for example, recently reformulated its range of drinks to include allulose, while Cocomels launched a sugar-free version of its coconut milk caramel candy sweetened with allulose and monk fruit, making it keto-friendly and free of sugar alcohols.
The continued popularity of the keto diet will also likely give allulose a boost since the sweetener is keto-compliant.
In 2021, DouxMatok will be launching in the US an upgraded version of its "enhanced sugar" (a patented technology that makes sugar taste sweeter) that uses fiber as a carrier instead of the previously used silica.
Nestlé in 2018 launched Wowsomes, a product featuring its new hollow sugar technology which reduced sugar 30%. In February 2020, the company announced that it had discontinued the line, perhaps highlighting that this product may have been ahead of its time. Despite the response to this chocolate product, the technology remains revolutionary and we can expect to see it being used in other products, targeting adults rather than children.
In light of the renewed focus on healthy eating and weight loss at this juncture of the pandemic, expect greater interest in such technology.
GARBANZO: GOOD TO GREAT
The chickpea began its journey to greatness at some point in the early 2000s when hummus migrated from middle-eastern eateries and into deli sections across the US. Americans have continued to adopt chickpea-based products in many forms since and it's still featuring among our top food trend predictions for 2021.
The experimentation happening now with both chickpea flour and aquafaba (chickpea soaking water) is the springboard for future chickpea-based trends. Flatbreads and crusts made from chickpea flour will migrate from Italy and France into American frozen food sections.
Look for socca flatbreads and fainâ based pizzas to be available in retail outlets near you. Dairy-free ice cream, macarons, and meringues made with aquafaba will also take a center stage of our food prediction trends for 2021 as consumers clamor for plant-based versions of their favorite sweets.
As with most new trends, food service would have normally been the place to start such trends. However, as the pandemic forced restaurants to shutter and people to stay at home, we may see a leapfrogging of trends directly to retail. Chickpea flour, which is already used in many parts of the world, will become a coveted ingredient for consumers looking to regain their pre-pandemic health levels through homemade recipes.
Currently, 1 in 3 launches in the US featuring chickpeas as an ingredient is from startups, but expect this to rise as innovation featuring chickpeas comes to the fore.
Chickpea-based ice cream and cakes are finding growing appeal not just among those following a plant-based lifestyle, but also those looking for better-for-you options for an indulgent treat.
While there's still a bit of confusion surrounding the legality of CBD, it hasn't stopped the plant medicine from becoming a worldwide phenomenon.
For those still leery of crossing the legal line in search of a remedy for inflammation, chronic pain, and anxiety, Copaiba may be the answer. Copaiba, a completely legal essential oil derived from the resin of the Copaifera tree contains terpenes that interact with the endocannabinoid system in the body to purportedly provide similar therapeutic benefits to CBD.
Added sparingly to elixirs and edibles, copaiba has a woodsy, sweet flavor and aroma conducive to relaxation. Our food trend predictions for 2021 suggest you keep an eye open for copaiba.
Copaiba's growth is likely to have been stalled by the pandemic, which saw the natural and organic space focus on growing their core portfolio rather than on expanding into new ingredients. At the same time, the need for such ingredients is higher than ever before.
The WHO estimates that around 300 million people around the world suffer from an anxiety disorder, a number that is expected to only go up in light of the COVID-19 pandemic.
People are dealing with high levels of anxiety, depression, lack of motivation, and stress due to unemployment, their financial situation, the economy, isolation, and other reasons related to the pandemic. Products, such as copaiba, can go a long way in helping them better cope.
In addition, the FDA has recommended new enforcement guidance for CBD. While no details are known yet, such legal issues will continue to plague CBD products, opening up the need for relaxation aids that come with less legal baggage.
So even though interest in copaiba may have waned a bit in light of the pandemic, we can expect to see a renewal in the coming year as people attempt to bring back calm into their lives.
DoTerra often showcases recipes that feature the use of its copaiba essential oil.
CLIMATARIANS ARE COMING!
Climate change is top- of- mind for food trends 2021. It seems the world is in dire peril and the time to change course is NOW! Vegans have been doing their part to combat climate change by avoiding meat for years, but a more comprehensive approach is coming.
This includes the elimination of all foods with a high carbon footprint; such as meat and cheese, eating only locally grown and seasonal foods, and avoiding products that exploit animals at risk from climate change. Foods to add to a climatarian diet would include algae, seaweed, pulses, grains and legumes, invasive species of plants, fish, and insects.
Diets with low environmental impacts are becoming all the rage.
Interest in sustainable diets increased by 151.7% in the last five years and by 55.5% in the last year alone.
The pandemic will force companies to shift their focus away from climate-friendly food innovation. Overall innovation has been stalled with many companies choosing to delay or cancel new product launches or development. The slowdown in global trade and production of related ingredients will have tempered innovation within the climate-friendly food space as well.
But the one thing that the pandemic has proved is that, if we're careful, we can actually have a positive impact on the environment. Expect consumer demand for eco-friendly packaging to grow and product manufacturers to take up this cause.
Reducing carbon footprint and enhancing the sustainability of packaged goods, which ultimately will help slow down climate change, is going to be the lynchpin to attract the climatarian consumer. Upcycling packaging will also see a rise.
This noodles product from Paldo in the US includes both chlorella and seaweed.
Silverfin Fish Cakes are made


Etsy Launch: How To Open An Etsy Shop Like A Professional Seller | Tiffany Emery | Skillshare
Tiffany Emery, 7-Figure Etsy Seller & Etsy BusinesCoach
Tiffany Emery, 7-Figure Etsy Seller & Etsy BusinesCoach
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15 Lessons (1h 59m)
 - 1. Intro
 - 2. Welcome
 - 3. The Extraordinary Etsy Marketplace
 - 4. What Is The Etsy Algorithm?
 - 5. Why Launch?
 - 6. The 6 Rules of Etsy Engagement
 - 7. Rule 1: Create A Standout Marketable Product
 - 8. Rule 2: Create A Trustworthy Brand Image
 - 9. Rule 3: Take Scroll-Stopping Photography
 - 10. Rule 4: Write Descriptions That Eliminate Questions
 - 11. Rule 5: Set Competitive Pricing & Shipping Structures
 - 12. Rule 6: Understand Search & Research Your SEO
 - 13. LAUNCH! Part 1
 - 14. LAUNCH! Part 2
 - 15. Conclusion + Bonus Lesson Offer
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About This Class
Avoid the #1 mistake new sellers make and don't just OPEN your Etsy Shop, LAUNCH it!
Join 7-figure Etsy seller, Tiffany Emery, to learn step-by-step how to launch your creative business on Etsy. From creating a marketable product to branding and competitive pricing, Tiffany walks you through the ins & outs of how to find success on the Etsy platform.
This class provides a deep dive into the following topics:
 - Etsy Algorithm - The 2-step process that leads shoppers to your listing
 - Benefits of Launching - Why gradually opening can actually limit your success
 - The Rules of Etsy Engagement - How to create the most engaging, fully optimized listing for your shoppers
 - How to Set up Your Shop - Watch over Tiffany's shoulder as she walks you through a full tutorial of how to set up your first listing.
Follow along in your Pre-Launch Workbook, where you'll learn exactly where to focus for your best chance at Etsy success! After you complete this class, you'll be well on your way to building a successful online business on Etsy with an actionable punch list to get it done.
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Tiffany Emery
7-Figure Etsy Seller & Etsy BusinesCoach
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1. Intro: Hi, I'm Tiffany. I'm a small business owner, creative entrepreneur, and seven figure Etsy seller. In this class, I'll help you to bypass the number one mistake I see most new shop owners make. Not just open your shop, but instead launch your Etsy shop in each of your Etsy listings to their fullest potential. Etsy as a marketplace provides an incredible opportunity to launch a business. When I started my business, I was a new mom working my day job full-time and working on my Etsy shop in the market creating digital nursery artwork. I had no idea the power of this platform, but it has completely changed my life. There are so many items you can sell on Etsy, everything from handmade ceramics, jewelry, personalized items, vintage items, praecipes, even digital downloads, and so much more. I know that right now is non-pristine time so many people who need to pivot into a new career or extended online arm for their business. Or maybe they have this amazing skill, but they just didn't know how to leverage it into a business and have no idea where to start. Whether you're a maker, an artist, designer, or illustrator, there's plenty of room for you on Etsy. Etsy can be the perfect launching ground for a new business. As a seasoned seller, I'm going to teach you exactly where I would focus today in opening a shop or publishing a new listing. I'll break down what matters most when it comes to getting sales on Etsy, and that is engagement. What is it and how do we get it? I'll share my six rules of Etsy engagement and teach you how to engage with the human shoppers who are trying to find you and me, Etsy machine that will bring them right to your virtual front door. Then come look over my shoulders as I actually opened a shop and follow along with my punch list of items to get it done in your pre-launch workbook. It's your dream to work for yourself, make your own hours and spend more time with your family. While creating what you love, Etsy offers you an enormous opportunity to launch the career of your dreams as a creative entrepreneur. If not now, then when? I believe in you and I'm here to show you how to put your best foot forward into the extraordinary empty marketplace. Come along with me, let me take you by the hand and let's launch an Etsy shop. 2. Welcome: Welcome to the class. My name is Tiffany Emery, and I'm a full-time Etsy seller, and have been selling on Etsy for the last six years through my shop, Adorn Studio. I am so thrilled that you're here. You've made a really important decision, getting educated about Etsy, and that's going to pay off for you in the long run. But before we get started, I did want to be sure to draw your attention to the projects and resources tab where you'll find your pre-launch workbook. This workbook is going to be your class project, that you'll be working through as you prepare to launch your Etsy shop. Now, we do have some work ahead of us, but don't let that sway you from digging in and getting started. I want to share with you the number one mistake that most new shop owners make, to encourage you as you prepare for your launch. What most of new shop owners do, is they basically have no idea how to launch a shop. The path that they usually take, is to gradually open their shop. They figure out their shop name and, then they open their shop. They wait a little while, and then decide to start working on a listing. Then they come up against listing items that they aren't familiar with, or maybe they just don't understand the importance of them. They half fill out a listing. Maybe they have some good photos, or maybe not, but they figured they can upload what they have, and then come back and keep working on their photos later. They usually have no idea what SEO is, which we'll cover in this course. That's completely left out, and then they publish their listing. Then after some time passes, they realize that their shop isn't doing so well. They'll do some research and figure out that they needed to work on their photography. To do that for a little bit, or they needed to optimize [inaudible] for the Etsy search engine so they work on that for a little bit, and little by little, by little, they gradually open the full door to their Etsy shop. Friends, this is a huge mistake. There are a number of reasons why you shouldn't gradually open your shop, and instead launch your shop strong and fully optimized. I'm going to explain them to you throughout this course. But just note that your pre-launch workbook will take you some time, and that's okay. In fact, it's a good thing. It's going to give you an edge over what most sellers do incorrectly. Just remember, it's not a race, it's a strategic launch. You need to prepare to fully throw the doors of your shop open, and launch for the highest probability of success on Etsy. Your pre-launch book is designed to walk you step-by-step through how to prepare for your launch. You'll be ready to launch your shop, and your first listing when you've completed all six sections of the workbook for at least one listing. You'll work through your workbook for each listing that you launch. The workbook includes the following sections: Section 1, Market Research; Section 2, Branding Basics; Section 3, Photography; Section 4, Descriptions; Section 5, Pricing and Shipping Structures; and Section 6, SEO Basics. Once you've completed all the items in your workbook, you're ready to launch your shop. In the last two lessons of this class, I'll walk you through exactly how to do that. So take your time and get it right for the highest payoff possible for all of your hard work. Now let's get started. 3. The Extraordinary Etsy Marketplace: In this lesson, I want to talk about what sets Etsy apart as a marketplace, because it's truly an extraordinary place to sell. Etsy touts itself as a global marketplace and community of sellers empowered to make a living doing what they love, while allowing buyers to find the unique items that


Modulation of the trigeminofacial pathway during syllabic speech
Meredith Estep, Steven M. Barlow
Research output: Contribution to journalArticlepeer-review
10 Scopus citations
The human orofacial system is richly endowed with low-threshold, slowly adapting mechanoreceptors that respond to self-generated movements and external loads. The functional linkage between these afferents and the recruitment of motor units in the lower face during the dynamics of speech is unknown. Mechanically evoked activity in the orbicularis oris muscles was studied in young human female adults (N = 10) during a lip force recruitment task associated with the repetition of the nonsense speech utterance "ah-wah." This speech task involved the recruitment of perioral motor units against an elastic load. A skin contactor probe coupled to a servo-controlled linear motor delivered punctate ipsilateral mechanical inputs (25 ms duration, 1800 μm displacement) to the glabrous surface of the upper lip in order to index the modulation and specificity of the compound trigeminofacial response as a function of speech force recruitment threshold (Ft). Modulation of the early (Ft = 0.2 N) and later (Ft = 1.0 N) components of the evoked perioral response was found at the two force thresholds. Beginning at approximately 60 ms post-stimulus, a significant suppression response was found among lower lip EMG recording sites and its magnitude was greatest when the mechanical perturbation occurred during the early phase of lip force recruitment. Variation in the lip force trajectories was manifest by a greater difference in net interangle force associated with lip perturbations indexed to the early Ft. This was interpreted to reflect the operation of a feedforward mechanism which may play a more significant role during an evolving speech action. Thus, the application of servo-controlled mechanosensory inputs effectively indexed the excitability of the facial motor nucleus during production of a simple speech phrase. Future studies are needed to explore mechanisms of short-term adaptation and trigeminofacial modulation during propositional speech in health and disease.
Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalBrain Research
Issue number1
StatePublished - Sep 26 2007
Externally publishedYes
 - Active force
 - Compound perioral response
 - Electromyography
 - Mechanical stimulation
 - Orbicularis oris
ASJC Scopus subject areas
 - Neuroscience(all)
 - Molecular Biology
 - Clinical Neurology
 - Developmental Biology
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text:
Epidermal Regeneration of Cultured Autograft, Allograft, and Xenograft Keratinocytes Transplanted on Full-Thickness Wounds in Rabbits.
From the Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
|OBJECTIVES: Skin grafting has been evolving as an important application in reconstructive surgery. Mixed reports about the survival of allogeneic and xenogeneic keratinocytes require further substantiation to determine the role of these cells in wound healing. MATERIALS AND METHODS:Rabbit and rat skins were recovered and cultured in vitro. Full-thickness wounds were created on the dorsum of rabbits (2 cm × 2 cm; n = 4). Cultured epithelial autograft, allograft, and xenograft cellswere sprayed onto 3 freshly created wounds, with 1 wound acting as a control. The wounds were monitored every 2 days for 4 weeks. After 4 weeks, the rabbits were killed; skin biopsies were taken from each healed wound and stained with hematoxylin and eosin, and epidermal thickness was measured.
RESULTS: All examined grafts showed favorable healing outcomes because the wounds appeared similar to normal skin upon healing. The only observed significant difference was the thickness of the epidermis layer, which was thinner in the xenograft (P =.002) than the autograft or allograft. Morphologic evaluation of the skin surface showed that the rat skin was thinner than the rabbit skin. The graft that achieved the best result was the autograft because the thickness was similar to and mimicked normal skin.
CONCLUSIONS: All 3 grafts (autograft, allograft, and xenograft) have the potential to reconstitute epithelial defects. This approach can overcome the limitation of autologous skin donor sites, especially in burn cases.


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Players can match 3 or more stars by their color by dragging one star to many other stars of the same color. Matching 3 stars will give the player 10 points. The stars can be arranged in a column, a row, or just touching each other as seen in the picture to the right. When more than 4 stars are matched, a super star is made, and it will emit a supernova that blasts away the stars near it (even stars that don't match it) once that star is matched.
The star meter of the left of the screen needs to be filled up. The meter can be filled up by matching stars. When the meter is completely filled up, the player advances to the next level.
From level 3 and onwards, a lock will be set on a random star at times. This prevents the player to move the row and column where the locked star is located. The lock can be removed by matching three or more stars of the same color as the locked star with that locked star.
Since there is no time limit, the player can end the game by clicking on the lock at the bottom of the screen. A gem is given to the player once they get 4,000+ points. The game also ends when there are no more available moves due to a certain amount to locked stars.
There is a glitch in Staries, where if the player waits before making a move for a long time, a large amount of locks are set on stars. This may or may not be a glitch, and rather locks may be set depending on how long it takes for the player to make a move.
- Spanish: Estrellitas (Little Stars)
- Japanese: STARIES どろどろスター (Sutarisu dorodor suta, Staries?? Star)


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MathWorks news stories
Women in Technology
On the front line: Perspectives from women in the tech industry
October 8 marked Ada Lovelace Day, a memorial for the first computer programmer. But it was a lot more than celebrating one woman's achievements.
What we can learn from the car's journey to AI
A quick rundown of the history of computers and cars and the lessons we can learn about coming out on top.
Taking a look at the growing trend of text analytics
Using text analytics, engineers can extract more value from raw text and combine it with sensor data and ML to improve a range of functions.
Machine learning vs deep learning: what's the difference?
Johanna Pingel from MathWorks talks about deep learning and how it's different from machine learning.
The future of wireless design with multi-functional engineers
It starts with enabling team members to become multi-functional engineers who can comfortably work in the digital, RF, and system domains.
Internet of Things
MathWorks announces release of matlab and simulink product families
"With the growth of smart devices and IoT, design teams face the challenge of creating more intelligent products and applications..."


The WPF text team has seen some people get confused about what units WPF uses when measuring text. Samer, a developer on the WPF text team, and I have created this post to try and shed some light on this subject. The first part of this post is very straight forward, whereas the end will only be useful for those of you who are extensively using WPF text APIs.
General Units
WPF supports multiple units for text measurement. The units that can be used are "px" (device independent pixels), "in" (inches), "cm" (centimeters), "pt" (points). If you do not specify the unit of measurement, WPF defaults to px.
To force WPF to use a different unit of measurement, just append the unit abbreviation to the FontSize.
Hello World
Device Independent Pixels & Physical Pixels
In accordance with WPF's resolution independence, the framework measures objects in device independent pixels. These device independent pixels can have different sizes than physical pixels.
1 device independent pixel = 1/96 inch.
1 physical pixel = 1/DPI (dependent on the system DPI)
Default system settings usually choose a DPI of 96 so these two types of pixels come out to be the same size. If this is not the case, it is easy to convert between the two types of pixels.
physical pixels = DPI/96 * device independent pixels
device independent pixels = 96/DPI * physical pixels
Notice that as the DPI increases, so does the number of physical pixels which compose one device independent pixel. Hence, objects that have their sizes specified in device independent pixels get larger as the system DPI increases.
A point (pt) is also a common unit of measurement for fonts.
1pt = 1/72 inches
Converting between points and device independent pixels is also easy.
pt = 72/96 device independent pixels
device independent pixels = 96/72 pt
Remember objects which are measured in device independent pixels get larger as system DPI increases? This is true for text. Since there is a constant ratio between point sizes/device independent pixels, if the point size of text is held constant while the system DPI is increased, the size of the rendered text will grow.
Uses For Font Units
Aside from knowing how to correctly set FontSize, the above knowledge could be helpful in understanding the values that WPF text APIs, such as FormattedText or TextFormatter, use and return for the different text measurements. The metrics returned from these APIs are in device independent pixel (eg. some properties of GlyphTypeface including Baseline, CapsHeight, XHeight). When interacting with these APIs make sure that you convert to device independent pixels from whatever unit your font is measured in, or visa versa.
- Samer and Chipalo


In this article we will walk through working with an already created People Flow. First, we will talk through adding people to a People Flow and then about how to add and editing the steps of the flow.
There are a number of ways to add people to people flows.
 1. From within the People Flow itself
 2. From a person's profile
 3. Using Mass Manage, a form, or another People Flow
From within the People Flow
To add people to a People Flow from within a particular flow, you first need to click into a particular step of the flow.
This will take you to a screen such as the one below. To add a person, simply press the 'Add Person to This Step' button and search for their name.
From their Profile
To add someone to a People Flow from within their profile, simply click 'Add to People Flow' in the blue sidebar.
This will bring up an 'Add to people flow' window. Simply select the flow you want to add them to.
Then simply the step, or steps you want to add them to, and assign an administrator.
Using Mass Manage, Forms or other People Flow steps
To add an individual or a group of people to a flow using the Mass Manage or Forms features, simply select the option of 'Add to People Flow' in the first action dropdown. Select the People Flow you want to add them to, and then assign which step and administrator.
That's it! Just follow the directions above and you will be able to add people into an already created People Flow.
Adding/Editing a new People Flow Step
To add a step to a People Flow from within the flow, press the 'Add Step' button.
Editing an existing People Flow step
To edit an existing People Flow step, simply select 'Edit' next to the step.
Both of these options bring up the same window. From this window you can edit a number of settings.
Some of the more important areas to pay attention to:
Due Date
This setting changes when a person is 'due' to be completed from the step. For instance, you may want someone to be processed immediately when added to a step, or the step might require that they are processed a set number of days after being added. There are a number of settings available – most of them are relative to the date they were added to the people flow step.
Hide Pending
This setting changes when people due within the flow will appear on the assigned administrator's dashboard, relative to when the person is due. For instance, if 'John Bubble' is due to be actioned on the 15th of March, and the 'Hide Pending' setting is set to 4 days, John won't appear on the dashboard until the 11th of March.
This setting changes if you want an email to be sent to the administrators of the People Flow step when someone is added to the step. If this option is selected and a person is added to the People Flow step without being assigned to an administrator, an email will be sent out to all administrators. If they have been assigned to an administrator, only the assigned administrator will receive the email.
These settings allow you to define the People Flow actions that are to be made upon completion of a step. You can choose from a range of actions, allowing you to change people's information, people categories, groups etc.
The 'Automated' setting for actions allows you to define whether you want the action to be applied to every person that goes through the step.
If you have any questions on any of these processes, please feel free to reach out to us directly at and we will be able to help you from there :)
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The etymology of the name Philéole
What does the name Philéole mean and where does this name and our slogan "Make the wind your friend" come from?
Philéole is the contraction of two words that come from ancient Greek. The first is Phil, from the ancient Greek φίλος, phílos, which means "friend, person who loves". The second is Eole. In Greek mythology, Aeolus, Αἴολος, Aíolos, is the master and steward of the winds.
Make wind your friend!
History of Philéole
The history and creation of Philéole; where we got the idea to produce a mini wind turbine.
Philéole arose from the desire to use the force of the wind with bio-based and ecological means. The wind is everywhere around us, with different forces, stable or turbulent. It is present in all countries and in all types of environment; whether it is an energetically isolated environment to a hyper-connected urban environment, whether it is a marine or terrestrial environment.
In 2014, after several months of development, studies, models and prototypes, the concept of the Philéole mini wind turbine emerged. The mini wind turbine is tested in a wind tunnel at the University of Liège, in the Vrije University of Brussels and at the Von Karman institute so that Philéole can present a successful product: a bio sourced wind turbine for independent and renewable, urban energy production. and domestic, respectful of nature, biodegradable and recyclable.
Initially, Philéole focused on the production of the mini nautical wind turbine: ready to serve sailors in France and around the world, the Philéole mini nautical wind turbine attached to the top of the mast of the boat, in full wind, collects energy whatever the wind direction at sea, at anchor, in winter.
A few months later, Philéole decided to expand the possibilities of using its mini wind turbine. With its patents for Europe and the world, the Philéole mini wind turbine is now a unique product in a limitless market; ready to collect energy from the roofs of country houses and tiny houses, city buildings, or any place where the wind blows.
Every day, the Philéole team seeks to improve the performance and design of its vertical wind turbine to offer a unique and successful product.
Our main goals
The primary goal of Philéole is energy independence and ecology. By offering a unique product, Philéole wishes to take advantage of the elements of nature for independence in the production and consumption of energy. To push the ecological side further, Philéole decides to produce its mini wind turbine out of corn starch and aluminum; two elements that are either biodegradable or recyclable.
Most wind turbines available on the market pick up winds that blow at high altitude and require extensive earthworks. Today, Philéole focuses on the energies developed by light airs, turbulences and currents. Philéole wishes to use this energy and make it available to sites located outside the distribution networks.
Philéole team members
Graduated in industrial design at La Cambre. Founder of a line of high-end furniture in steel and micro-concrete and of an art gallery. Maxime works on the design of wind turbine structures, optimising the design for production and reducing the ecological impact of wind turbines. He likes to be part of sustainable solutions for a better future for all.
Graduated in mechanical engineering at UCLouvain. Passionate about aeronautics and wind behaviour. Grégoire puts his skills at the service of Philéole to dimension the mechanical parts of the wind turbines, to define the performances of the wind turbine, to check that the wind turbine works in an optimal way and respects our requirements and those of the customers.
Diplômé de l'Université de technologie de Delft, c'est un passionné de l'aéronautique


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The PDI App by Equilibria enables you to find out your E-Colors personality style through 35 quick questions.
For many people knowledge and understanding of the E-Colors leads to heightened self-awareness and awareness of others. Become familiar with your Strengths and Potential Limiters as you start your journey towards realizing your potential. The E-Colors process has been used by thousands of people worldwide to improve areas such as communication, self-development, teamwork, leadership and risk management.
The free version of the PDI App will provide you with the following:
- Background information about the E-Colors Process
- The PDI Questionnaire to establish your own E-Colors
- Free access to your PDI Results Chart
- Free access to your E-Colors Personality Report
- Ability to share your E-Colors results with friends & family
Upgrade to the full version and gain access to the following:
- Access to all 12 E-Color Reports
- Access to the 12 Quirks & Traits of each E-Color group
- Information about the Strengths & Potential Limiters of each E-Color group
- Access to the Communication Slide Rule


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Dust in your ear holes, dust in your eye.
Dust in those knickers you hung out to dry…
Whilst many coastal and bush land communities suffered the ravages of fire and flood this summer, some rural Australian towns suffer under the blanket of giant dust storms that can turn day into night and envelop everything in their path.
We spoke to Sarah Chamberlain, Director of Little Diggers Preschool and Childcare in Lightning Ridge, to find out how they deal with the dust storms, what they do to keep children safe and how they foster a positive mindset.
Lack of rain is drying out plants and topsoil across huge areas of country Australia. When conditions are right, the dry red dust gets picked up by wind gusts and carried hundreds of kilometres across Australia and even out to sea.
Towns like Lightning Ridge and Broken Hill in NSW are being swept by these giant dust storms more than once a month, all year round. Up to 15 dust storms were recorded across 2019 in these areas.
"You can feel a dust storm coming," says Sarah. "The air feels heavy and thick – just like that pressure or tension when a storm is coming. You can see this dark cloud on the horizon – at first you hope that it will bring rain. When you realise it's dust you have to quickly pack up all the outside areas, get all the children inside and close all the doors and windows.
"The children are 'wired', some of them understand what's happening but many are confused. We put on the air conditioner and do indoor activities all day."
It's the cumulative effect of the long drought, severe water restrictions and the increase in the number and severity of dust storms that weighs people down, says Sarah.
Dealing with the aftermath can be demoralising.
"We spent hours sweeping the red dust from the windows, doors and outdoor furniture after the last dust storm," shares Sarah. "If you've left anything out on the washing line you just have to re-wash. Some people can't be bothered to clean away the layers of dust from their doors and window sills because it will just get covered with dust again when the next one comes."
While the dirt and residue left by dust storms can be annoying and disheartening, it's the growing health concerns that are most worrying. Doctors are reporting a rise in the number of adults and children with asthma. This rise has been apparent even among people who previously had no difficulty breathing. Signs of difficulty breathing include: chest tightness, wheezing, coughing or shortness of breath.
"One thing you're hit with is the reality that water is so precious," says Sarah. "We need to look after it because we rely on it so much. We've been doing activities to learn about how important water is for survival and the need to save water.
"For outdoor play in the mud kitchen we fill the water container that has measuring markings inside and the children are told that's the only water they will get all day. We've also done experiments to show how plants need water to live.
"We also find ways to focus on kindness, gratitude, being grateful for what we do have. We want to support the wellbeing of the children and educators so we can be there for each other through the challenges that people face."
How Dust Storms Form
For dust storms to form, the soil needs to be dry and exposed.
Then you need strong winds that can pick up the soil and carry it across long distances. Just how powerful the wind needs to be depends on the size of the dust particles, but the minimum speed is about 30 kilometres per hour.
The storms are more likely to form if there's an unstable atmosphere that can lift the dust into the air.
Bureau of Meteorology (BOM) forecaster Jonathan How told ABC News that a classic example of an unstable atmosphere occurs ahead of a trough or a cold front, where air is rising, or before thunderstorms.
And the dust is likely to stay in the air and travel if there are dry conditions
Mr How says if the atmosphere is moist, there's a greater chance of seeing the dust particles condense into clouds or rain — or the dust could join together and become too heavy to be carried by the wind.
Precautions to take during a dust storm
- Stay indoors as much as possible, particularly if you are at risk of health problems.
- Close the windows, doors and vents.
- If possible, stay in an air-conditioned room.
- If you have to go outside, wear a mask over your mouth and nose to prevent you from breathing in dust. A P2 or P3 mask, available from a hardware store should be effective.
- Avoid exercise, particularly if outdoors.
- Be aware of any children with asthma or other conditions and their action plan or treatment plan.
(Reference: Dust Storms | healthdirect)


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Radiology Image Transfer
Leg Length Discrepancy
Leg Length Discrepancy
What is a leg length discrepancy?
Leg length discrepancy means one leg is longer than the other. Discrepancies as small as a few centimeters can set off a chain of events, causing your child to walk and stand differently, which can lead to hip, knee, and/or ankle problems, and can lead to functional scoliosis (a curve in the spine caused by an underlying condition). Leg length discrepancies can be congenital (from birth). They also can be caused by bone disease, bone tumors, the treatments used to eliminate bone tumors, injuries that don't heal properly, and a number of other causes.
There are generally two kinds of leg length discrepancies:
- Structural discrepancy. This occurs when a leg bone is shorter than its corresponding bone in the other leg. For example, the thigh bone (femur) or the shin bone (tibia) is sometimes shorter in one leg.
- Functional discrepancy. This occurs when a condition above the leg causes the discrepancy. For example, a hip dislocation can cause this kind of discrepancy.
What are the symptoms of a leg length discrepancy?
Because children's bodies respond differently to leg length discrepancies, symptoms can vary. Common symptoms include:
- Obvious differences in length. While a discrepancy is not always obvious, if you are aware of a discrepancy, consult a physician.
- Problems with posture or gait. This might include limping, rotating the leg while walking, or toe-walking.
- Pain. The pain may occur in the ankle, knee, hip, or back.
How is a leg length discrepancy treated?
There are some nonsurgical treatments, such as orthotics, but often surgery is necessary to correct the discrepancy. Because children are still growing, the goal of surgery is not to correct the leg lengths for the current height of your child but to ensure leg lengths will be equal when your child is finishing growing. Often, this means your orthopaedic surgeon will need to take a series of measures over the course of 1-2 years in order to accurately predict your child's future height.
Each type of surgery for leg length discrepancy has its advantages and disadvantages. Options include:
- Epiphysiodesis. In this surgery, a bony ridge is fastened to the growth plate of the longer leg, preventing the leg from growing more and allowing the shorter leg to catch up.
- Epiphyseal stapling. In this surgery, staples are inserted into the growth plate of the longer leg, which slows down its growth.
- Bone resection. In this surgery, a section of bone is removed from the longer leg in order to match the size of the shorter leg.
- Leg lengthening procedures. Procedures to lengthen the shorter leg provide a child with the ability to reach his or her maximum height, but they also are technically difficult procedures, involving extended and painful physical rehabilitation and sometimes involving complications, such as wound infections, dislocations of the hip or knee, and other problems.
The best surgery for your child will depend on many factors, such as the size of the discrepancy, whether your child is finished growing, and other factors. Your orthopaedic surgeon will work closely with your family to help you make the best decision for your child's unique needs.
About surgery for leg length discrepancies at Children's
The surgeries for leg discrepancies are performed by the accomplished pediatric orthopaedic surgery team at Children's. Orthopaedic surgery teams at Children's provide next-generation care to children from throughout the Upper Midwest and consistently perform some of the most cutting-edge surgical procedures available, including minimally invasive surgery, when appropriate. Leg discrepancy surgeries are performed at Children's – Minneapolis and Children's - St. Paul.
- If you are a family member and you'd like to make an appointment at our clinic locations in Minneapolis or St. Paul, please call Children's Orthopaedic Clinic main line at _PHONE_.
- If you are a health professional looking for a consultation or referral information, please call Children's Orthopaedic Clinic main line at _PHONE_.


text:
Are Grades 10-12 physical sciences teachers equipped to teach physics?
MetadataShow full item record
South African schools have been confronted with educational reform since the mid-nineties and the process is still continuing. The concomitant changes put a very high demand on physical sciences teachers and also have an impact on teacher behaviour. The purpose of this study was to probe whether teachers could be considered equipped to teach the physics part of the FET physical sciences curriculum. A revised framework on teacher behaviour, which includes three factors, namely teacher knowledge, teacher views and beliefs, and teacher attitudes, was used in conjunction with a questionnaire and a survey to analyse the data from individual and focus group interviews. A total of 68 FET physical sciences teachers from urban, township and rural schools participated in the research. Our findings indicate that teachers are positive about the curriculum. However, the problems identified with training, support and resources as well as the lack of teachers' subject content knowledge, particularly in rural and township schools, cannot be blamed on the curriculum and therefore cannot be fixed by curriculum changes.


metarush/perm
Role-based access control (RBAC) with custom rules (like ABAC)
v3.0.0 2020-06-14 20:13 UTC
This package is auto-updated.
Last update: 2022-05-15 00:42:44 UTC
README
Perm allows you to implement role-based access control (RBAC) functionality in your app with optional custom rules (like ABAC).
Install
Install via composer as metarush/perm
Usage
Perm expects you to provide the following arrays:
 - $roleRanks: hierarchy of roles
 - $roleResources: list of resources roles has access to
 - $resourceRestrictions: list of restrictions resources have that must validate before access is granted
array $roleRanks
An array where keys represent roleIds while the values represent their hierarchy. Example:
$roleRanks = [
 1 => 1,
 2 => 2,
 3 => 3
]
Keys 1,2,3 represent roleIds in your app. This could mean that 1 represents an admin, 2 a moderator, 3 a staff.
Values 1,2,3 represent their hierarchy. Lower value means a higher rank.
Note: Resources of a lower role are inherited by higher roles. E.g., Resources of a role with rank 3 are inherited by roles with a rank 2 and 1.
array $roleResources
An array where keys represent roleIds while values represent an array of resourceIds the roleId has access to. Example:
$roleResources = [
 1 => ['1','2'],
 2 => ['3','4'],
 3 => ['5','6']
];
Keys 1,2,3 represent roleIds in your app. This could mean that 1 represents an admin, 2 a moderator, 3 a staff.
Values ['1','2'], ['3','4'], ['5','6'] represent resourceIds in your app. This could mean that 1 represents "create user", 2 "edit user", 3 "create post", and so on.
You may notice that the values are strings. This is so you could literally use strings like 'createUser' as it can also act as identifiers. Doing this, you may skip explicitly creating a list of numerical resourceIds, as long as your app can handle it.
Alternative example:
$roleResources = [
 1 => ['createUser', 'editUser'],
 2 => ['createPost','editPost'],
 3 => ['readPost', 'createComment']
];
Perm does not care how you name your roles or resources.
array $resourceRestrictions
An array where keys represent resourceIds while values represent an array of restrictions that are allowed. Restrictions in Perm are represented by the following public constants:
Perm::RESTRICTION_PERMISSION
Allow if the role has an explicit permission. E.g., "moderator" role has "create user" permission.
Perm::RESTRICTION_CUSTOM_RULE
Allow if the custom rule is met
Perm::RESTRICTION_OWNER
Allow if the requesting user is the owner of the resource
Perm::RESTRICTION_CUSTOM_RULE_AND_OWNER
Allow if the custom rule is met and the requesting user is the owner of the resource
Perm::RESTRICTION_PERMISSION_AND_CUSTOM
Allow if the role has explicit permission and if the custom rule is met
Example:
$resourceRestrictions = [
 '1' => [
 Perm::RESTRICTION_PERMISSION
 ],
 '2' => [
 Perm::RESTRICTION_PERMISSION,
 Perm::RESTRICTION_OWNER
 ],
 '3' => [
 Perm::RESTRICTION_CUSTOM_RULE
 ],
 '4' => [
 Perm::RESTRICTION_CUSTOM_RULE_AND_OWNER
 ]
 '5' => [
 Perm::RESTRICTION_PERMISSION_AND_CUSTOM_RULE
 ]
];
Keys 1,2,3,4, 5 represent resourceIds in your app. This could mean 1 represents "create user", 2 "edit post", 3 "delete post", 4 "delete comment", 5 "delete user".
Values represent their restrictions that Perm understands. This is how Perm will interpret the abve example:
 - resourceId 1 or "create user" resource, is allowed if the role of the requesting user has an explict "create user" permission.
 - resourceId 2 or "edit post" resource, is allowed if the role of the requesting user has an explict "edit post" permission, or, if the requesting user is the owner of the resource
 - resourceId 3 or "delete post" resource, is allowed if its custom rule is met. E.g., any rule you set like "post can be deleted if x". The rule is customizable in your own code as long as it returns a boolean value.
 - resourceId 4 or "delete comment" resource, is allowed if its custom rule is met and if the requesting user is the owner of the resource.
 - resourceId 5 or "delete user" resource, is allowed if the role has explicit permission and if its custom rule is met
As you can see in resourceId 2, you can combine restrictions as you wish.
When using combined restrictions, only one restriction that validates is required to grant access. E.g., In resourceId 2, access is granted if the user has explicit permission for resourceId 2 or if its custom rule validates.
Optional custom classes
PermissionInterface $ownerFinder
This custom class that you create will be used as the owner finder for a given resource.
Required by:
 - Perm::RESTRICTION_OWNER
 - Perm::RESTRICTION_CUSTOM_RULE_AND_OWNER
Use the ->setOwnerFinderFactoryFqn($ownerFinderFactoryFqn) method in the builder to apply this custom class through a factory class that you will also create.
PermissionInterface $customRules
This custom class that you create will be used as the custom rule handler for a given resource.
Required by:
 - Perm::RESTRICTION_CUSTOM_RULE
 - Perm::RESTRICTION_CUSTOM_RULE_AND_OWNER
 - Perm::RESTRICTION_PERMISSION_AND_CUSTOM_RULE
Use the ->setCustomRulesFactoryFqn($customRulesFactoryFqn) method in the builder to apply this custom class through a factory class that you will also create.
To sum it up, if you're going to create an owner finder class then you also need to create a factory class that instantiates and returns your owner finder class. Likewise, if you're going to create a custom rules class, create a factory class for it too.
For an example on how to implement these custom classes, see the tests/unit/Samples folder.
Init the library
In your middleware, controller, or top of your app:
use MetaRush\Perm;
$perm = (new Perm\Builder)
 ->setRoleRanks($roleRanks)
 ->setRoleResources($roleResources)
 ->setResourceRestrictions($resourceRestrictions)
 ->setOwnerFinderFactoryFqn(Perm\Samples\MyOwnerFinderFactory::class) // optional
 ->setCustomRulesFactoryFqn(Perm\Samples\MyCustomRulesFactory::class) // optional
 ->build();
Create a Request object
$userId = 5; // userId of the requesting user
$roleId = 3; // roleId of $userId e.g., "staff"
$resourceId = 'addUser'; // resourceId of the requested resource
$serverRequest = $psr7serverRequest; // optional PSR-7 ServerRequestInterface object
$request = new Perm\Request($userId, $roleId, $resourceId, $serverRequest);
The above values are arbitrary data depending to your app. The optional $serverRequest parameter can be used in your custom rules.
Pass the Request object to Perm's hasPermission()method:
if (!$perm->hasPermission($request))
 exit('Access denied');
// access allowed, continue with the app...
That's the idea on how to use Perm. The CRUD functions, or database of users, roles , and resources, are not included in this library as they are best implemented in userland -- since they are typically unique per project. The important thing to remember is to make them compatible with the three arrays required by Perm as discussed previously:
 - $roleRanks
 - $roleResources
 - $resourceRestrictions


Purpose of installing elevators
Elevators are so far one of the best invention and technology in our lives. Without them there would be no concept of such tall buildings having multiple floors. This invention has given a new turn to our vision as we are able to move from one floor to another without any stress or physical strain. All we have to do is to press the button of our desirable floor and here we go. You will see different types of elevator in Dubai like dumbwaiters, passenger lifts, service lifts and much more. All these different types possess different capability and mission to accomplish. They are not intended to be used in the same way but their purpose is more or less same which is to transport things from one floor to another. If you are willing to install an elevator then you will get a wide range of good options among which Mitsubishi elevator is on the top. In this article we will talk about the purposes that why there is a need of installing elevators?
To facilitate disable people
Not all people are same because some may have mobility issues. This disability could be by birth, due to any disease or accident. For such type of people it is impossible to climb even a single step of stair which will be quite frustrating for them as they are unable to go to different floors independently. Elevators came up as a blessing for such people as now they can easily go from one floor to another without anyone's assistance. This give a source of motivation and confidence to such people beside of their sad reality.
To reach top most floors
In Dubai you will see a lot of huge buildings which are actually touching skies and seem to be never ending. These buildings may have even fifty to hundred floors. Would you think that without elevators you could be able to reach those floors? Obviously not! This is the main purpose of installing elevators to reach the higher floors without causing any manual effort and consuming less time.
Reduce the chances of accidents
Climbing up a staircase is usually risky as there are a lot of chances that you may fall accidentally. This is more common for children who are quite careless during climbing the stairs and also for the elderly people who are physically weak and are unable to maintain balance. In such case elevators is the best option as it will reduce such type of incidents.


text:
Updated: Mar 20
There are so many ways to be brave.
Sometimes being brave means saying yes, even though you're scared. Sometimes being brave means saying no, even though you're scared. But being brave will always mean being at least a little bit scared, and doing the scary thing anyway.
Here's to all the brave balloons floating through the sky, terrified, and flying anyway.
1. Support the child to blow up the balloon, taking big, deep, belly breaths. (If they are unable to do so, do it for them, while they breathe along with you!)
2. Take turns kicking/heading/hitting the balloon into the air, aiming to keep it from hitting the floor
3. Any time the balloon hits the floor, share a time you were brave.
P.S If you want to learn more about using therapeutic stories just like this one, check out my Therapeutic Storytelling Workshop by clicking HERE!


text:
Joseph Brant (Thayendanegea), 1776
oil on canvas
127 x 101.6 cm
Transfer from the Canadian War Memorials, 1921
National Gallery of Canada (no. 8005)
During the American Revolutionary War, the Mohawk leader Joseph Brant (_PHONE_) was given the rank of captain and fought on the side of the British. This portrait was painted on the occasion of Brant's trip to England to negotiate the role of the Iroquois Confederation of the Six Nations in the conflict. He wears the silver gorget (a piece of armour for the throat) presented to him by George III. His Mohawk name, Thayendanegea, means "two sticks bound together", denoting strength.
Frame: running moulding with carved ornament, gilded. Britain, second hald 18th century


text: The aim of the present study was to evaluate the effect of local melatonin application during surgery on bone implant connection (BIC) in rabbit tibiae. Six 0.8- to 1-year-old male New Zealand rabbits were divided into 3 groups: (1) a control group (CG) in which rabbits were not treated with additive materials and only implant integration was executed; (2) a melatonin dose 1 (MLT D-1) group in which rabbits were treated with 1.2 mg of melatonin locally before implant placement into the rabbits' tibiae; and (3) a melatonin dose 2 (MLT D-2) group in which rabbits were treated with 3 mg melatonin locally before implant placement into the rabbits' tibiae. Four weeks after the procedure, the rabbits were euthanized; their tibiae were dissected from muscles and soft tissues, fixed with formaldehyde, and later embedded in methacrylate. Histologic and histomorphometric analyses were then performed under light microscopy. Following this, BIC was detected histomorphometrically, and P<.05 was considered statistically significant. Results showed that the highest BIC percentage was detected in MLT D-2, with a mean value of 39.46% +/- 0.78, as compared with a mean value of 33.89% +/- 0.92 in group MLT D-1 and 27.42% +/- 0.89 in CG. Similarly, the mean BIC percentage of the MLT D-2 group was the highest among the three, with the mean BIC percentage of the MLT D-1 still registering as higher than CG. Within the limitations of this rabbit study, it appears that local melatonin application during implant surgery may improve BIC.


text:
النشيد الوطني الفلسطيني فدائي | Palestinian National Anthem (AR/EN)
The Palestinian national anthem ( Fida'i), is the national anthem of Palestine. It was adopted by the Palestinian Liberation Organization in 1996, in accordance with Article 31 of the Palestinian Declaration of Independence from 1988. It was written by Said Al Muzayin (a.k.a. Fata Al Thawra, boy of the revolution), its music was composed by Egyptian maestro Ali Ismael, and it was known as the anthem of the Palestinian redemption.


Second Annual Cora Weiss Fellowship for Young Women Peacebuilders
Second Annual Cora Weiss Fellowship for Young Women Peacebuilders
The Global Network of Women Peacebuilders is pleased to announce its second annual Cora Weiss Fellowship for Young Women Peacebuilders. The Fellowship aims to support the development of young women peacebuilders and ensure that more young people share Cora's vision for sustainable peace and gender equality as strong and integral parts of our global culture. Applications must be submitted in English, and emailed to .
Eligibility requirements
 To be eligible for the Cora Weiss Fellowship, applicants must meet the following criteria:
1. At least one year experience of volunteering or employment in a women's rights/human rights/peace advocacy organization;
2. One year experience in policy advocacy on women's rights, human rights, peace and other social justice issues, including understanding of the UN Security Council Resolution 1325 on Women, Peace and Security, and related laws and policies;
3. A Bachelor's degree in international relations, women/gender studies or the social sciences; and
4. Has lived or worked in a developing country for at least one year.
5. Since the fellowship will take place in New York where the international community is mainly congregated, proficiency in the English language is a must.
 Selection criteria
 Applicants will be evaluated based on the following criteria:
1. Ability to use the skills and networking opportunities gained from this Fellowship in a similar undertaking, such as working with a civil society organization that advocates for women, peace and security, for at least 2 years after completion of the Fellowship;
2. Ability to communicate effectively on women, peace and security issues; and
3. Ability and willingness to travel to conflict-affected countries.
 (Note: GNWP closely monitors the security situation in all the countries it works in to ensure that it is safe for its staff and members and partners to travel. However, some of the countries where GNWP implements its work are still experiencing violent conflicts or are still impacted by the aftermath of conflict. The Cora Weiss Fellow will have to sign a contract agreeing to travel.)
 The successful applicant will have the opportunity to work with GNWP for one year on its global advocacy in the UN to promote the implementation of the UN Security Council Resolutions (UNSCR) 1325 and 1820 on Women, Peace and Security, and related laws and policies. In addition, the applicant will also have the opportunity to participate in GNWP's national and local initiatives such as the Localization of UNSCR 1325 and 1820, and Girl Ambassadors for Peace.
The Fellowship year will commence in May 2017 and end in May 2018. It will cover roundtrip airfare from the country of origin to New York, room and board, health insurance, local transportation, and other personal expenses of the fellow.
 Checklist of required documents
1. Completed application form in English. Please note that while GNWP has released this advertisement in different languages, submission of a completed application in English is essential. The application form is available here.
2. An essay of no more than 3 pages that explains why you are applying for the Cora Weiss Fellowship
3. Two letters of reference. Reference letters should include how long the writer has known the applicant and in what capacity, comments on the applicant's potential to make an impact in the field of women, peace and security, and any relevant prior experience.
Applications may be sent to: All required application materials should be complete and submitted together in one e-mail. Documents sent separately will not be reviewed and application will be considered incomplete. Deadline for application is November 1, 2016.
Focus areas:


text:
If you love green salsa, then you should get to know tomatillos. Dating back to 800 B.C., when the Aztecs domesticated them, tomatillos are considered a key ingredient in Latin-American cooking. Also called "tomate verde" in Mexico, the fruit of the tomatillo is generally firm, green, about the size of a large cherry, and meatier than a tomato. They grow to maturity inside a light brown, papery husk. The husk is a good indicator of freshness, but is inedible and should be removed before use.
The fruit of the tomatillo can be used as a base for chili sauces, known generically as salsa verde (green sauce), and will help lessen the pepper's hot flavor as well as stimulate the appetite. Because of their tart quality, tomatillos can be cooked, eaten raw, minced or pureed to accompany prepared dishes. Tomatillo's also makes a great addition to tortilla soup or guacamole.


Mayo Clinic Symptom Checker Fatigue at Symptom
Best symptom Tips and References website . Search anything about symptom Ideas in this website.
Mayo Clinic Symptom Checker Fatigue. Signs of dehydration, such as no wet diapers over eight to 10 hours, crying without tears, a dry mouth or refusing to drink any fluids. Nmo is commonly misdiagnosed as multiple sclerosis.
Mayo Clinic Q&A podcast "Brain fog" is a lingering
Mayo Clinic Q&A podcast "Brain fog" is a lingering from _URL_
Pittock, m.d., is researching an inflammatory disease of the central nervous system that causes swelling and inflammation of the eye nerves and the spinal cord (neuromyelitis optica, or nmo). Find possible causes of symptoms in children and adults. Hypothyroidism is treated medically by replacing the body's hormone with a medication that is taken daily for life.
Mayo Clinic Q&A podcast "Brain fog" is a lingering
They are among the common symptoms that almost every liver patient experiences. Is accompanied by chest pain that lasts more than a few minutes. Some disorders of the thyroid gland cause it to be overactive and make too much hormone. I bounced around from doctor to doctor for the longest time!


smallstring-0.1.0: A string type optimized for size in memory
The SmallString type is for storing small identifiers. We do not provide fast operations on strings - what we offer is low memory overhead.
The Ord instance is not guaranteed to be the same as that of the corresponding string.
data SmallString Source
A space efficient representation of text. This is like a strict ByteString, but with fewer features, and UTF preserving. Fow ASCII data, we're slightly smaller than ByteStrings for small strings.
fromString :: String -> SmallStringSource
Convert a String into a SmallString.
toString :: SmallString -> StringSource
Convert a SmallString into a String.


Story: Sexual health
Syphilis and gonorrhoea were a source of deep shame, embarrassment and denial in the 19th and 20th centuries. During the First World War, Ettie Rout pioneered a safe-sex approach to minimise sexually transmitted infections among servicemen – but others opposed her and tried to promote abstinence instead. From the 1980s HIV/AIDS brought a new sense of urgency to sexual-health initiatives, and condoms became a symbol of safe sex.
Story by Jane Tolerton
Main image: VD prevention poster, 1980s
Story summary
All images & media in this story
Sexually transmitted infections are diseases passed on by having sex. Sexual health means attempts to control, prevent and cure these infections. Approaches to stop the spread of disease have varied over time – sometimes blaming infected people and insisting on abstinence (no sex), at other times supporting infected people and promoting safe sex.
Venereal disease
Venereal disease (VD) meant syphilis and gonorrhoea. There was no effective treatment for these before penicillin became available.
 - Syphilis could kill people or make them insane. Babies infected with syphilis in the womb were often born deformed, or died before birth.
 - Gonorrhoea could make women sterile, and make babies blind.
Early approaches to venereal disease
Venereal disease was believed to be due to immoral sexual behaviour. Infected people were often too ashamed to get treatment. When someone died from syphilis, their family sometimes pretended that the cause of death was something else.
Information about sex and sexual health was banned, so it was difficult for people to learn about venereal disease and how to prevent it.
Prostitutes were blamed for spreading venereal disease. From 1869 to 1910, under the Contagious Diseases Act, women suspected of prostitution could be forcibly examined for diseases, then locked up and treated.
First and Second world wars
Many New Zealand soldiers in Europe during the First World War caught venereal diseases. At first, safer sex practices such as condoms were not encouraged. But from 1917, servicemen going on leave were given kits that included condoms, developed by Christchurch woman Ettie Rout. She set up a brothel in Paris where servicemen could have safe sex.
In the Second World War servicemen were given condoms – but many still caught diseases. Some American servicemen stationed in New Zealand infected local women.
In the early 21st century chlamydia was New Zealand's most common sexually transmitted infection. Before the mid-1970s it was unknown; many cases of what was then called non-specific urethritis in men would now be recognised as chlamydia. Many people with chlamydia have no symptoms, but it can cause infertility.
HIV/AIDS arrived in New Zealand in the 1980s. People infected with HIV could develop AIDS, which made their immune systems fail. At first, most people with HIV died, but since the mid-1990s treatments have kept people alive longer, and pills to prevent infection were introduced in the 2010s.
Many cases of HIV were in the gay community, and gay activists organised to stop the disease spreading and to support people with HIV. They encouraged people to have safe sex and use condoms.
After prostitution was decriminalised in 2003, it became illegal for clients of prostitutes to have sex without a condom.
How to cite this page:
Jane Tolerton, 'Sexual health', Te Ara - the Encyclopedia of New Zealand, (accessed 25 January 2021)
Story by Jane Tolerton, published 5 May 2011, reviewed & revised 7 Dec 2018


What is Minimum Production Speed, and why is it necessary?
Minimum Production Speed is the minimum speed at which the machine is considered to be running in production operation; for most machines it should be set to 1 unit rate of production. This parameter is defined to provide some customers with a method to represent actual machine status for specific machines in a way that […]
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