Compared to primaquine phosphate what was the result of primaquine phosphate and dihydroartemisinin-piperaquine on maximum observed plasma concentration after oral administration (Cmax) and predicted area under the plasma concentration time curve after the last dose from zero time to infinity (AUC0–last)values?
Combined administration with dihydroartemisinin-piperaquine resulted in significantly lower primaquine CL/F (P = 0.0229) and V/F (P = 0.0013) values than administration alone, leading to significantly higher Cmax (P = 0.0019) and AUC0–last (P = 0.0200) values. This also resulted in a shorter primaquine t1/2 (P = 0.0005) than with administration alone.