import torch
import torch.nn as nn
from torchvision import models
import torch.nn.functional as F

from functools import partial

# import Constants

nonlinearity = partial(F.relu, inplace=True)


class DACblock(nn.Module):
    def __init__(self, channel):
        super(DACblock, self).__init__()
        self.dilate1 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.dilate2 = nn.Conv2d(channel, channel, kernel_size=3, dilation=3, padding=3)
        self.dilate3 = nn.Conv2d(channel, channel, kernel_size=3, dilation=5, padding=5)
        self.conv1x1 = nn.Conv2d(channel, channel, kernel_size=1, dilation=1, padding=0)
        for m in self.modules():
            if isinstance(m, nn.Conv2d) or isinstance(m, nn.ConvTranspose2d):
                if m.bias is not None:
                    m.bias.data.zero_()

    def forward(self, x):
        dilate1_out = nonlinearity(self.dilate1(x))
        dilate2_out = nonlinearity(self.conv1x1(self.dilate2(x)))
        dilate3_out = nonlinearity(self.conv1x1(self.dilate2(self.dilate1(x))))
        dilate4_out = nonlinearity(self.conv1x1(self.dilate3(self.dilate2(self.dilate1(x)))))
        out = x + dilate1_out + dilate2_out + dilate3_out + dilate4_out
        return out


class DACblock_without_atrous(nn.Module):
    def __init__(self, channel):
        super(DACblock_without_atrous, self).__init__()
        self.dilate1 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.dilate2 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.dilate3 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.conv1x1 = nn.Conv2d(channel, channel, kernel_size=1, dilation=1, padding=0)
        for m in self.modules():
            if isinstance(m, nn.Conv2d) or isinstance(m, nn.ConvTranspose2d):
                if m.bias is not None:
                    m.bias.data.zero_()

    def forward(self, x):
        dilate1_out = nonlinearity(self.dilate1(x))
        dilate2_out = nonlinearity(self.conv1x1(self.dilate2(x)))
        dilate3_out = nonlinearity(self.conv1x1(self.dilate2(self.dilate1(x))))
        dilate4_out = nonlinearity(self.conv1x1(self.dilate3(self.dilate2(self.dilate1(x)))))
        out = x + dilate1_out + dilate2_out + dilate3_out + dilate4_out

        return out

class DACblock_with_inception(nn.Module):
    def __init__(self, channel):
        super(DACblock_with_inception, self).__init__()
        self.dilate1 = nn.Conv2d(channel, channel, kernel_size=1, dilation=1, padding=0)

        self.dilate3 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.conv1x1 = nn.Conv2d(2 * channel, channel, kernel_size=1, dilation=1, padding=0)
        for m in self.modules():
            if isinstance(m, nn.Conv2d) or isinstance(m, nn.ConvTranspose2d):
                if m.bias is not None:
                    m.bias.data.zero_()

    def forward(self, x):
        dilate1_out = nonlinearity(self.dilate1(x))
        dilate2_out = nonlinearity(self.dilate3(self.dilate1(x)))
        dilate_concat = nonlinearity(self.conv1x1(torch.cat([dilate1_out, dilate2_out], 1)))
        dilate3_out = nonlinearity(self.dilate1(dilate_concat))
        out = x + dilate3_out
        return out


class DACblock_with_inception_blocks(nn.Module):
    def __init__(self, channel):
        super(DACblock_with_inception_blocks, self).__init__()
        self.conv1x1 = nn.Conv2d(channel, channel, kernel_size=1, dilation=1, padding=0)
        self.conv3x3 = nn.Conv2d(channel, channel, kernel_size=3, dilation=1, padding=1)
        self.conv5x5 = nn.Conv2d(channel, channel, kernel_size=5, dilation=1, padding=2)
        self.pooling = nn.MaxPool2d(kernel_size=3, stride=1, padding=1)

        for m in self.modules():
            if isinstance(m, nn.Conv2d) or isinstance(m, nn.ConvTranspose2d):
                if m.bias is not None:
                    m.bias.data.zero_()

    def forward(self, x):
        dilate1_out = nonlinearity(self.conv1x1(x))
        dilate2_out = nonlinearity(self.conv3x3(self.conv1x1(x)))
        dilate3_out = nonlinearity(self.conv5x5(self.conv1x1(x)))
        dilate4_out = self.pooling(x)
        out = dilate1_out + dilate2_out + dilate3_out + dilate4_out
        return out



class PSPModule(nn.Module):
    def __init__(self, features, out_features=1024, sizes=(2, 3, 6, 14)):
        super().__init__()
        self.stages = []
        self.stages = nn.ModuleList([self._make_stage(features, size) for size in sizes])
        self.bottleneck = nn.Conv2d(features * (len(sizes) + 1), out_features, kernel_size=1)
        self.relu = nn.ReLU()

    def _make_stage(self, features, size):
        prior = nn.AdaptiveAvgPool2d(output_size=(size, size))
        conv = nn.Conv2d(features, features, kernel_size=1, bias=False)
        return nn.Sequential(prior, conv)

    def forward(self, feats):
        h, w = feats.size(2), feats.size(3)
        priors = [F.upsample(input=stage(feats), size=(h, w), mode='bilinear') for stage in self.stages] + [feats]
        bottle = self.bottleneck(torch.cat(priors, 1))
        return self.relu(bottle)


class SPPblock(nn.Module):
    def __init__(self, in_channels):
        super(SPPblock, self).__init__()
        self.pool1 = nn.MaxPool2d(kernel_size=[2, 2], stride=2)
        self.pool2 = nn.MaxPool2d(kernel_size=[3, 3], stride=3)
        self.pool3 = nn.MaxPool2d(kernel_size=[5, 5], stride=5)
        self.pool4 = nn.MaxPool2d(kernel_size=[6, 6], stride=6)

        self.conv = nn.Conv2d(in_channels=in_channels, out_channels=1, kernel_size=1, padding=0)

    def forward(self, x):
        self.in_channels, h, w = x.size(1), x.size(2), x.size(3)
        self.layer1 = F.upsample(self.conv(self.pool1(x)), size=(h, w), mode='bilinear')
        self.layer2 = F.upsample(self.conv(self.pool2(x)), size=(h, w), mode='bilinear')
        self.layer3 = F.upsample(self.conv(self.pool3(x)), size=(h, w), mode='bilinear')
        self.layer4 = F.upsample(self.conv(self.pool4(x)), size=(h, w), mode='bilinear')

        out = torch.cat([self.layer1, self.layer2, self.layer3, self.layer4, x], 1)

        return out


class DecoderBlock(nn.Module):
    def __init__(self, in_channels, n_filters):
        super(DecoderBlock, self).__init__()

        self.conv1 = nn.Conv2d(in_channels, in_channels // 4, 1)
        self.norm1 = nn.BatchNorm2d(in_channels // 4)
        self.relu1 = nonlinearity

        self.deconv2 = nn.ConvTranspose2d(in_channels // 4, in_channels // 4, 3, stride=2, padding=1, output_padding=1)
        self.norm2 = nn.BatchNorm2d(in_channels // 4)
        self.relu2 = nonlinearity

        self.conv3 = nn.Conv2d(in_channels // 4, n_filters, 1)
        self.norm3 = nn.BatchNorm2d(n_filters)
        self.relu3 = nonlinearity

    def forward(self, x):
        x = self.conv1(x)
        x = self.norm1(x)
        x = self.relu1(x)
        x = self.deconv2(x)
        x = self.norm2(x)
        x = self.relu2(x)
        x = self.conv3(x)
        x = self.norm3(x)
        x = self.relu3(x)
        return x


class CE_Net_(nn.Module):
    def __init__(self, num_classes=1, num_channels=3):
        super(CE_Net_, self).__init__()

        filters = [64, 128, 256, 512]
        resnet = models.resnet34(pretrained=True)
        self.firstconv = resnet.conv1
        self.firstbn = resnet.bn1
        self.firstrelu = resnet.relu
        self.firstmaxpool = resnet.maxpool
        self.encoder1 = resnet.layer1
        self.encoder2 = resnet.layer2
        self.encoder3 = resnet.layer3
        self.encoder4 = resnet.layer4

        self.dblock = DACblock(512)
        self.spp = SPPblock(512)

        self.decoder4 = DecoderBlock(516, filters[2])
        self.decoder3 = DecoderBlock(filters[2], filters[1])
        self.decoder2 = DecoderBlock(filters[1], filters[0])
        self.decoder1 = DecoderBlock(filters[0], filters[0])

        self.finaldeconv1 = nn.ConvTranspose2d(filters[0], 32, 4, 2, 1)
        self.finalrelu1 = nonlinearity
        self.finalconv2 = nn.Conv2d(32, 32, 3, padding=1)
        self.finalrelu2 = nonlinearity
        self.finalconv3 = nn.Conv2d(32, num_classes, 3, padding=1)

    def forward(self, x):
        # Encoder
        x = self.firstconv(x)
        x = self.firstbn(x)
        x = self.firstrelu(x)
        x = self.firstmaxpool(x)
        e1 = self.encoder1(x)
        e2 = self.encoder2(e1)
        e3 = self.encoder3(e2)
        e4 = self.encoder4(e3)

        # Center
        e4 = self.dblock(e4)
        e4 = self.spp(e4)

        # Decoder
        d4 = self.decoder4(e4) + e3
        d3 = self.decoder3(d4) + e2
        d2 = self.decoder2(d3) + e1
        d1 = self.decoder1(d2)

        out = self.finaldeconv1(d1)
        out = self.finalrelu1(out)
        out = self.finalconv2(out)
        out = self.finalrelu2(out)
        out = self.finalconv3(out)

        return F.sigmoid(out)

class CE_Net_backbone_DAC_without_atrous(nn.Module):
    def __init__(self, num_classes=1, num_channels=3):
        super(CE_Net_backbone_DAC_without_atrous, self).__init__()

        filters = [64, 128, 256, 512]
        resnet = models.resnet34(pretrained=True)
        self.firstconv = resnet.conv1
        self.firstbn = resnet.bn1
        self.firstrelu = resnet.relu
        self.firstmaxpool = resnet.maxpool
        self.encoder1 = resnet.layer1
        self.encoder2 = resnet.layer2
        self.encoder3 = resnet.layer3
        self.encoder4 = resnet.layer4

        self.dblock = DACblock_without_atrous(512)


        self.decoder4 = DecoderBlock(512, filters[2])
        self.decoder3 = DecoderBlock(filters[2], filters[1])
        self.decoder2 = DecoderBlock(filters[1], filters[0])
        self.decoder1 = DecoderBlock(filters[0], filters[0])

        self.finaldeconv1 = nn.ConvTranspose2d(filters[0], 32, 4, 2, 1)
        self.finalrelu1 = nonlinearity
        self.finalconv2 = nn.Conv2d(32, 32, 3, padding=1)
        self.finalrelu2 = nonlinearity
        self.finalconv3 = nn.Conv2d(32, num_classes, 3, padding=1)

    def forward(self, x):
        # Encoder
        x = self.firstconv(x)
        x = self.firstbn(x)
        x = self.firstrelu(x)
        x = self.firstmaxpool(x)
        e1 = self.encoder1(x)
        e2 = self.encoder2(e1)
        e3 = self.encoder3(e2)
        e4 = self.encoder4(e3)

        # Center
        e4 = self.dblock(e4)
        # e4 = self.spp(e4)

        # Decoder
        d4 = self.decoder4(e4) + e3
        d3 = self.decoder3(d4) + e2
        d2 = self.decoder2(d3) + e1
        d1 = self.decoder1(d2)

        out = self.finaldeconv1(d1)
        out = self.finalrelu1(out)
        out = self.finalconv2(out)
        out = self.finalrelu2(out)
        out = self.finalconv3(out)

        return F.sigmoid(out)

class CE_Net_backbone_DAC_with_inception(nn.Module):
    def __init__(self, num_classes=1, num_channels=3):
        super(CE_Net_backbone_DAC_with_inception, self).__init__()

        filters = [64, 128, 256, 512]
        resnet = models.resnet34(pretrained=True)
        self.firstconv = resnet.conv1
        self.firstbn = resnet.bn1
        self.firstrelu = resnet.relu
        self.firstmaxpool = resnet.maxpool
        self.encoder1 = resnet.layer1
        self.encoder2 = resnet.layer2
        self.encoder3 = resnet.layer3
        self.encoder4 = resnet.layer4

        self.dblock = DACblock_with_inception(512)


        self.decoder4 = DecoderBlock(512, filters[2])
        self.decoder3 = DecoderBlock(filters[2], filters[1])
        self.decoder2 = DecoderBlock(filters[1], filters[0])
        self.decoder1 = DecoderBlock(filters[0], filters[0])

        self.finaldeconv1 = nn.ConvTranspose2d(filters[0], 32, 4, 2, 1)
        self.finalrelu1 = nonlinearity
        self.finalconv2 = nn.Conv2d(32, 32, 3, padding=1)
        self.finalrelu2 = nonlinearity
        self.finalconv3 = nn.Conv2d(32, num_classes, 3, padding=1)

    def forward(self, x):
        # Encoder
        x = self.firstconv(x)
        x = self.firstbn(x)
        x = self.firstrelu(x)
        x = self.firstmaxpool(x)
        e1 = self.encoder1(x)
        e2 = self.encoder2(e1)
        e3 = self.encoder3(e2)
        e4 = self.encoder4(e3)

        # Center
        e4 = self.dblock(e4)
        # e4 = self.spp(e4)

        # Decoder
        d4 = self.decoder4(e4) + e3
        d3 = self.decoder3(d4) + e2
        d2 = self.decoder2(d3) + e1
        d1 = self.decoder1(d2)

        out = self.finaldeconv1(d1)
        out = self.finalrelu1(out)
        out = self.finalconv2(out)
        out = self.finalrelu2(out)
        out = self.finalconv3(out)

        return F.sigmoid(out)

class CE_Net_backbone_inception_blocks(nn.Module):
    def __init__(self, num_classes=1, num_channels=3):
        super(CE_Net_backbone_inception_blocks, self).__init__()

        filters = [64, 128, 256, 512]
        resnet = models.resnet34(pretrained=True)
        self.firstconv = resnet.conv1
        self.firstbn = resnet.bn1
        self.firstrelu = resnet.relu
        self.firstmaxpool = resnet.maxpool
        self.encoder1 = resnet.layer1
        self.encoder2 = resnet.layer2
        self.encoder3 = resnet.layer3
        self.encoder4 = resnet.layer4

        self.dblock = DACblock_with_inception_blocks(512)


        self.decoder4 = DecoderBlock(512, filters[2])
        self.decoder3 = DecoderBlock(filters[2], filters[1])
        self.decoder2 = DecoderBlock(filters[1], filters[0])
        self.decoder1 = DecoderBlock(filters[0], filters[0])

        self.finaldeconv1 = nn.ConvTranspose2d(filters[0], 32, 4, 2, 1)
        self.finalrelu1 = nonlinearity
        self.finalconv2 = nn.Conv2d(32, 32, 3, padding=1)
        self.finalrelu2 = nonlinearity
        self.finalconv3 = nn.Conv2d(32, num_classes, 3, padding=1)

    def forward(self, x):
        # Encoder
        x = self.firstconv(x)
        x = self.firstbn(x)
        x = self.firstrelu(x)
        x = self.firstmaxpool(x)
        e1 = self.encoder1(x)
        e2 = self.encoder2(e1)
        e3 = self.encoder3(e2)
        e4 = self.encoder4(e3)

        # Center
        e4 = self.dblock(e4)
        # e4 = self.spp(e4)

        # Decoder
        d4 = self.decoder4(e4) + e3
        d3 = self.decoder3(d4) + e2
        d2 = self.decoder2(d3) + e1
        d1 = self.decoder1(d2)

        out = self.finaldeconv1(d1)
        out = self.finalrelu1(out)
        out = self.finalconv2(out)
        out = self.finalrelu2(out)
        out = self.finalconv3(out)

        return F.sigmoid(out)


class CE_Net_OCT(nn.Module):
    def __init__(self, num_classes=12, num_channels=3):
        super(CE_Net_OCT, self).__init__()

        filters = [64, 128, 256, 512]
        resnet = models.resnet34(pretrained=True)
        self.firstconv = resnet.conv1
        self.firstbn = resnet.bn1
        self.firstrelu = resnet.relu
        self.firstmaxpool = resnet.maxpool
        self.encoder1 = resnet.layer1
        self.encoder2 = resnet.layer2
        self.encoder3 = resnet.layer3
        self.encoder4 = resnet.layer4

        self.dblock = DACblock(512)
        self.spp = SPPblock(512)

        self.decoder4 = DecoderBlock(516, filters[2])
        self.decoder3 = DecoderBlock(filters[2], filters[1])
        self.decoder2 = DecoderBlock(filters[1], filters[0])
        self.decoder1 = DecoderBlock(filters[0], filters[0])

        self.finaldeconv1 = nn.ConvTranspose2d(filters[0], 32, 4, 2, 1)
        self.finalrelu1 = nonlinearity
        self.finalconv2 = nn.Conv2d(32, 32, 3, padding=1)
        self.finalrelu2 = nonlinearity
        self.finalconv3 = nn.Conv2d(32, num_classes, 3, padding=1)

    def forward(self, x):
        # Encoder
        x = self.firstconv(x)
        x = self.firstbn(x)
        x = self.firstrelu(x)
        x = self.firstmaxpool(x)
        e1 = self.encoder1(x)
        e2 = self.encoder2(e1)
        e3 = self.encoder3(e2)
        e4 = self.encoder4(e3)

        # Center
        e4 = self.dblock(e4)
        e4 = self.spp(e4)

        # Decoder
        d4 = self.decoder4(e4) + e3
        d3 = self.decoder3(d4) + e2
        d2 = self.decoder2(d3) + e1
        d1 = self.decoder1(d2)

        out = self.finaldeconv1(d1)
        out = self.finalrelu1(out)
        out = self.finalconv2(out)
        out = self.finalrelu2(out)
        out = self.finalconv3(out)

        return out



class double_conv(nn.Module):
    def __init__(self, in_ch, out_ch):
        super(double_conv, self).__init__()
        self.conv = nn.Sequential(
            nn.Conv2d(in_ch, out_ch, kernel_size=3, padding=1),
            nn.BatchNorm2d(out_ch),
            nn.ReLU(inplace=True),
            nn.Conv2d(out_ch, out_ch, kernel_size=3, padding=1),
            nn.BatchNorm2d(out_ch),
            nn.ReLU(inplace=True)
        )

    def forward(self, x):
        x = self.conv(x)
        return x


class inconv(nn.Module):
    def __init__(self, in_ch, out_ch):
        super(inconv, self).__init__()
        self.conv = double_conv(in_ch, out_ch)

    def forward(self, x):
        x = self.conv(x)
        return x


class down(nn.Module):
    def __init__(self, in_ch, out_ch):
        super(down, self).__init__()
        self.max_pool_conv = nn.Sequential(
            nn.MaxPool2d(2),
            double_conv(in_ch, out_ch)
        )

    def forward(self, x):
        x = self.max_pool_conv(x)
        return x


class up(nn.Module):
    def __init__(self, in_ch, out_ch, bilinear=True):
        super(up, self).__init__()
        if bilinear:
            self.up = nn.Upsample(scale_factor=2, mode='bilinear', align_corners=True)
        else:
            self.up = nn.ConvTranspose2d(in_ch // 2, in_ch // 2, 2, stride=2)

        self.conv = double_conv(in_ch, out_ch)

    def forward(self, x1, x2):
        x1 = self.up(x1)
        diffX = x1.size()[2] - x2.size()[2]
        diffY = x1.size()[3] - x2.size()[3]
        x2 = F.pad(x2, (diffX // 2, int(diffX / 2), diffY // 2, int(diffY / 2)))
        x = torch.cat([x2, x1], dim=1)
        x = self.conv(x)
        return x


class outconv(nn.Module):
    def __init__(self, in_ch, out_ch):
        super(outconv, self).__init__()
        self.conv = nn.Conv2d(in_ch, out_ch, kernel_size=1)

    def forward(self, x):
        x = self.conv(x)
        return x


class UNet(nn.Module):
    def __init__(self, n_channels=3, n_classes=1):
        super(UNet, self).__init__()
        self.inc = inconv(n_channels, 64)
        self.down1 = down(64, 128)
        self.down2 = down(128, 256)
        self.down3 = down(256, 512)
        self.down4 = down(512, 512)
        self.up1 = up(1024, 256)
        self.up2 = up(512, 128)
        self.up3 = up(256, 64)
        self.up4 = up(128, 64)
        self.outc = outconv(64, n_classes)
        self.relu = nn.ReLU()

    def forward(self, x):
        x1 = self.inc(x)
        x2 = self.down1(x1)
        x3 = self.down2(x2)
        x4 = self.down3(x3)
        x5 = self.down4(x4)
        x = self.up1(x5, x4)
        x = self.up2(x, x3)
        x = self.up3(x, x2)
        x = self.up4(x, x1)
        x = self.outc(x)
        #x = self.relu(x)
        return F.sigmoid(x)