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Dec 29

From Cradle to Cane: A Two-Pass Framework for High-Fidelity Lifespan Face Aging

Face aging has become a crucial task in computer vision, with applications ranging from entertainment to healthcare. However, existing methods struggle with achieving a realistic and seamless transformation across the entire lifespan, especially when handling large age gaps or extreme head poses. The core challenge lies in balancing age accuracy and identity preservation--what we refer to as the Age-ID trade-off. Most prior methods either prioritize age transformation at the expense of identity consistency or vice versa. In this work, we address this issue by proposing a two-pass face aging framework, named Cradle2Cane, based on few-step text-to-image (T2I) diffusion models. The first pass focuses on solving age accuracy by introducing an adaptive noise injection (AdaNI) mechanism. This mechanism is guided by including prompt descriptions of age and gender for the given person as the textual condition. Also, by adjusting the noise level, we can control the strength of aging while allowing more flexibility in transforming the face. However, identity preservation is weakly ensured here to facilitate stronger age transformations. In the second pass, we enhance identity preservation while maintaining age-specific features by conditioning the model on two identity-aware embeddings (IDEmb): SVR-ArcFace and Rotate-CLIP. This pass allows for denoising the transformed image from the first pass, ensuring stronger identity preservation without compromising the aging accuracy. Both passes are jointly trained in an end-to-end way. Extensive experiments on the CelebA-HQ test dataset, evaluated through Face++ and Qwen-VL protocols, show that our Cradle2Cane outperforms existing face aging methods in age accuracy and identity consistency. Code is available at https://github.com/byliutao/Cradle2Cane.

  • 10 authors
·
Jun 25

IrokoBench: A New Benchmark for African Languages in the Age of Large Language Models

Despite the widespread adoption of Large language models (LLMs), their remarkable capabilities remain limited to a few high-resource languages. Additionally, many low-resource languages (e.g. African languages) are often evaluated only on basic text classification tasks due to the lack of appropriate or comprehensive benchmarks outside of high-resource languages. In this paper, we introduce IrokoBench -- a human-translated benchmark dataset for 16 typologically-diverse low-resource African languages covering three tasks: natural language inference~(AfriXNLI), mathematical reasoning~(AfriMGSM), and multi-choice knowledge-based QA~(AfriMMLU). We use IrokoBench to evaluate zero-shot, few-shot, and translate-test settings~(where test sets are translated into English) across 10 open and four proprietary LLMs. Our evaluation reveals a significant performance gap between high-resource languages~(such as English and French) and low-resource African languages. We observe a significant performance gap between open and proprietary models, with the highest performing open model, Aya-101 only at 58\% of the best-performing proprietary model GPT-4o performance. Machine translating the test set to English before evaluation helped to close the gap for larger models that are English-centric, like LLaMa 3 70B. These findings suggest that more efforts are needed to develop and adapt LLMs for African languages.

  • 26 authors
·
Jun 5, 2024

SynthBA: Reliable Brain Age Estimation Across Multiple MRI Sequences and Resolutions

Brain age is a critical measure that reflects the biological ageing process of the brain. The gap between brain age and chronological age, referred to as brain PAD (Predicted Age Difference), has been utilized to investigate neurodegenerative conditions. Brain age can be predicted using MRIs and machine learning techniques. However, existing methods are often sensitive to acquisition-related variabilities, such as differences in acquisition protocols, scanners, MRI sequences, and resolutions, significantly limiting their application in highly heterogeneous clinical settings. In this study, we introduce Synthetic Brain Age (SynthBA), a robust deep-learning model designed for predicting brain age. SynthBA utilizes an advanced domain randomization technique, ensuring effective operation across a wide array of acquisition-related variabilities. To assess the effectiveness and robustness of SynthBA, we evaluate its predictive capabilities on internal and external datasets, encompassing various MRI sequences and resolutions, and compare it with state-of-the-art techniques. Additionally, we calculate the brain PAD in a large cohort of subjects with Alzheimer's Disease (AD), demonstrating a significant correlation with AD-related measures of cognitive dysfunction. SynthBA holds the potential to facilitate the broader adoption of brain age prediction in clinical settings, where re-training or fine-tuning is often unfeasible. The SynthBA source code and pre-trained models are publicly available at https://github.com/LemuelPuglisi/SynthBA.

  • 6 authors
·
Jun 1, 2024

Artificial Intelligence-derived Vascular Age from Photoplethysmography: A Novel Digital Biomarker for Cardiovascular Health

With the increasing availability of wearable devices, photoplethysmography (PPG) has emerged as a promising non-invasive tool for monitoring human hemodynamics. We propose a deep learning framework to estimate vascular age (AI-vascular age) from PPG signals, incorporating a distribution-aware loss to address biases caused by imbalanced data. The model was developed using data from the UK Biobank (UKB), with 98,672 participants in the development cohort and 113,559 participants (144,683 data pairs) for clinical evaluation. After adjusting for key confounders, individuals with a vascular age gap (AI-vascular age minus calendar age) exceeding 9 years had a significantly higher risk of major adverse cardiovascular and cerebrovascular events (MACCE) (HR = 2.37, p < 0.005) and secondary outcomes, including diabetes (HR = 2.69, p < 0.005), hypertension (HR = 2.88, p < 0.005), coronary heart disease (HR = 2.20, p < 0.005), heart failure (HR = 2.15, p < 0.005), myocardial infarction (HR = 2.51, p < 0.005), stroke (HR = 2.55, p < 0.005), and all-cause mortality (HR = 2.51, p < 0.005). Conversely, participants with a vascular age gap below -9 years exhibited a significantly lower incidence of these outcomes. We further evaluated the longitudinal applicability of AI-vascular age using serial PPG data from the UKB, demonstrating its value in risk stratification by leveraging AI-vascular age at two distinct time points to predict future MACCE incidence. External validation was performed on a MIMIC-III-derived cohort (n = 2,343), where each one-year increase in vascular age gap was significantly associated with elevated in-hospital mortality risk (OR = 1.02, p < 0.005). In conclusion, our study establishes AI-vascular age as a novel, non-invasive digital biomarker for cardiovascular health assessment.

  • 5 authors
·
Feb 18

SynthRAD2023 Grand Challenge dataset: generating synthetic CT for radiotherapy

Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public challenges to provide data and evaluation metrics for comparing different approaches openly. This paper describes a dataset of brain and pelvis computed tomography (CT) images with rigidly registered CBCT and MRI images to facilitate the development and evaluation of sCT generation for radiotherapy planning. Acquisition and validation methods: The dataset consists of CT, CBCT, and MRI of 540 brains and 540 pelvic radiotherapy patients from three Dutch university medical centers. Subjects' ages ranged from 3 to 93 years, with a mean age of 60. Various scanner models and acquisition settings were used across patients from the three data-providing centers. Details are available in CSV files provided with the datasets. Data format and usage notes: The data is available on Zenodo (https://doi.org/10.5281/zenodo.7260705) under the SynthRAD2023 collection. The images for each subject are available in nifti format. Potential applications: This dataset will enable the evaluation and development of image synthesis algorithms for radiotherapy purposes on a realistic multi-center dataset with varying acquisition protocols. Synthetic CT generation has numerous applications in radiation therapy, including diagnosis, treatment planning, treatment monitoring, and surgical planning.

  • 9 authors
·
Mar 28, 2023

Multi-Dimensional Insights: Benchmarking Real-World Personalization in Large Multimodal Models

The rapidly developing field of large multimodal models (LMMs) has led to the emergence of diverse models with remarkable capabilities. However, existing benchmarks fail to comprehensively, objectively and accurately evaluate whether LMMs align with the diverse needs of humans in real-world scenarios. To bridge this gap, we propose the Multi-Dimensional Insights (MDI) benchmark, which includes over 500 images covering six common scenarios of human life. Notably, the MDI-Benchmark offers two significant advantages over existing evaluations: (1) Each image is accompanied by two types of questions: simple questions to assess the model's understanding of the image, and complex questions to evaluate the model's ability to analyze and reason beyond basic content. (2) Recognizing that people of different age groups have varying needs and perspectives when faced with the same scenario, our benchmark stratifies questions into three age categories: young people, middle-aged people, and older people. This design allows for a detailed assessment of LMMs' capabilities in meeting the preferences and needs of different age groups. With MDI-Benchmark, the strong model like GPT-4o achieve 79% accuracy on age-related tasks, indicating that existing LMMs still have considerable room for improvement in addressing real-world applications. Looking ahead, we anticipate that the MDI-Benchmark will open new pathways for aligning real-world personalization in LMMs. The MDI-Benchmark data and evaluation code are available at https://mdi-benchmark.github.io/

  • 13 authors
·
Dec 17, 2024 3