id
stringclasses 6
values | drug_name
stringclasses 6
values | condition_context
stringclasses 6
values | pre_drug_state_summary
stringclasses 6
values | on_drug_state_summary
stringclasses 6
values | post_drug_state_summary
stringclasses 6
values | observation_window
stringclasses 6
values | drift_vector
stringclasses 6
values | affected_system_axes
stringclasses 6
values | temporal_drift_profile
stringclasses 6
values | reversibility_flag
stringclasses 3
values | net_coherence_delta
stringclasses 4
values | notes
stringclasses 6
values | constraints
stringclasses 1
value | gold_checklist
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SDFE-001
|
SSRI
|
depression
|
Sleep fragmented; HRV low; appetite variable
|
Sleep latency improves; HRV flat; GI motility slows
|
Sleep regresses; GI normalizes
|
9 months
|
Neural calming + GI slowing
|
neural; gastrointestinal
|
Gradual onset; slow offset
|
partial
|
Neutral
|
Neural gain with GI cost
|
Under 220 words.
|
vector+axes+profile
|
SDFE-002
|
metformin
|
type2_diabetes
|
Glucose high variance; weight rising
|
Glucose variance down; appetite reduced; GI upset
|
Glucose stable; GI improves
|
12 months
|
Metabolic stabilization + GI perturbation
|
metabolic; gastrointestinal
|
Early GI hit then adaptation
|
yes
|
Positive
|
Classic metabolic drift
|
Under 220 words.
|
vector+axes+profile
|
SDFE-003
|
steroid
|
autoimmune_flare
|
Pain high; fatigue; labs variable
|
Pain down; sleep worse; glucose up
|
Rebound pain; fatigue persists
|
6 months
|
Inflammation suppression + metabolic stress
|
immune; metabolic; sleep
|
Fast onset; rebound offset
|
no
|
Negative
|
Suppression without repair
|
Under 220 words.
|
vector+axes+profile
|
SDFE-004
|
beta_blocker
|
arrhythmia
|
HR variability high; anxiety spikes
|
HR steadier; fatigue up
|
Fatigue resolves; HR variability returns
|
8 months
|
Autonomic damping
|
autonomic; cardiovascular
|
Immediate onset; clean offset
|
yes
|
Mixed
|
Control with energy cost
|
Under 220 words.
|
vector+axes+profile
|
SDFE-005
|
GLP1
|
obesity
|
Weight gain; appetite dysregulated
|
Weight loss; nausea; low intake
|
Weight stable; nausea gone
|
10 months
|
Appetite suppression + intake restructuring
|
metabolic; neural
|
Stepwise drift then plateau
|
yes
|
Positive
|
Strong appetite axis push
|
Under 220 words.
|
vector+axes+profile
|
SDFE-006
|
benzodiazepine
|
anxiety
|
Hyperarousal; insomnia
|
Anxiety low; sedation high
|
Rebound anxiety; sleep worse
|
7 months
|
Arousal suppression + dependence drift
|
neural; sleep
|
Immediate onset; rebound offset
|
no
|
Negative
|
Fragility fingerprint
|
Under 220 words.
|
vector+axes+profile
|
What this dataset tests
The whole-system drift pattern
induced by a single drug
over time.
Required outputs
- drift vector
- affected system axes
- temporal profile
- reversibility
- net coherence change
Use case
Foundation layer for the Drug-Induced System Drift Library.
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